Immunological and genetic kinetics from analysis to scientific development in continual lymphocytic leukemia
Background: Mechanisms driving the development of continual lymphocytic leukemia (CLL) from its early phases are usually not absolutely understood. The acquisition of molecular adjustments on the time of development has been noticed in a small fraction of sufferers, suggesting that CLL development isn’t primarily pushed by dynamic clonal evolution.
So as to make clear mechanisms that result in CLL development, we investigated longitudinal adjustments in each the genetic and immunological eventualities.
Strategies: We carried out genetic and immunological longitudinal evaluation utilizing paired main samples from untreated CLL sufferers that underwent scientific development (sampling at analysis and development) and from sufferers with steady illness (sampling at analysis and at long-term asymptomatic follow-up).
Outcomes: Molecular evaluation confirmed restricted and non-recurrent molecular adjustments at development, indicating that clonal evolution isn’t the principle driver of scientific development.
Our evaluation of the immune kinetics discovered an more and more dysfunctional CD8+ T cell compartment in progressing sufferers that was not noticed in these sufferers that remained asymptomatic.
Particularly, terminally exhausted effector CD8+ T cells (T-betdim/-EomeshelloPD1hello) accrued, whereas the the co-expression of inhibitory receptors (PD1, CD244 and CD160) elevated, together with an altered gene expression profile in T cells solely in these sufferers that progressed. As well as, malignant cells from sufferers at scientific development confirmed enhanced capability to induce exhaustion-related markers in CD8+ T cells ex vivo primarily by way of a mechanism depending on soluble components together with IL-10.
Conclusions: Altogether, we display that the interplay with the immune microenvironment performs a key position in scientific development in CLL, thereby offering a rationale for using early immunotherapeutic intervention.
Aquaphile Coelenterazine h, lyophilized solid |
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| 9-10127 | Biotium |
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Description: Minimum order quantity: 1 unit of 50uG |
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CF568 goat anti-mouse IgG(H+L) |
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| 9-20100 | Biotium |
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Description: Minimum order quantity: 1 unit of 1mg |
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CF568 goat anti-mouse IgG(H+L), highly cross-adsorbed |
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| 9-20101 | Biotium |
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Description: Minimum order quantity: 1 unit of 1mg |
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CF568 goat anti-rabbit IgG(H+L) |
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| 9-20102 | Biotium |
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Description: Minimum order quantity: 1 unit of 1mg |
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CF568 goat anti-rabbit IgG(H+L), highly cross-adsorbed |
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| 9-20103 | Biotium |
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Description: Minimum order quantity: 1 unit of 1mg |
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CF568 goat anti-chicken IgY (IgG) (H+L), highly cross-adsorbed |
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| 9-20104 | Biotium |
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Description: Minimum order quantity: 1 unit of 1mg |
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CF568 donkey anti-mouse IgG(H+L), highly cross-adsorbed |
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| 9-20105 | Biotium |
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Description: Minimum order quantity: 1 unit of 1mg |
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CF568 donkey anti-goat IgG(H+L), highly cross-adsorbed |
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| 9-20106 | Biotium |
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Description: Minimum order quantity: 1 unit of 1mg |
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CF568 rabbit anti-goat IgG(H+L) |
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| 9-20107 | Biotium |
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Description: Minimum order quantity: 1 unit of 1mg |
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CF568 goat anti-guinea pig IgG(H+L) |
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| 9-20108 | Biotium |
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Description: Minimum order quantity: 1 unit of 1mg |
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CF594 goat anti-mouse IgG(H+L) |
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| 9-20110 | Biotium |
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Description: Minimum order quantity: 1 unit of 1mg |
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CF594 goat anti-mouse IgG(H+L), highly cross-adsorbed |
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| 9-20111 | Biotium |
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Description: Minimum order quantity: 1 unit of 1mg |
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CF594 goat anti-rabbit IgG(H+L) |
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| 9-20112 | Biotium |
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Description: Minimum order quantity: 1 unit of 1mg |
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CF594 goat anti-rabbit IgG(H+L), highly cross-adsorbed |
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| 9-20113 | Biotium |
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Description: Minimum order quantity: 1 unit of 1mg |
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CF594 goat anti-chicken IgY (IgG) (H+L), highly cross-adsorbed |
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| 9-20114 | Biotium |
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Description: Minimum order quantity: 1 unit of 1mg |
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CF594 donkey anti-mouse IgG(H+L), highly cross-adsorbed |
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| 9-20115 | Biotium |
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Description: Minimum order quantity: 1 unit of 1mg |
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CF594 donkey anti-goat IgG(H+L), highly cross-adsorbed |
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| 9-20116 | Biotium |
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Description: Minimum order quantity: 1 unit of 1mg |
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CF594 rabbit anti-goat IgG(H+L) |
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| 9-20117 | Biotium |
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Description: Minimum order quantity: 1 unit of 1mg |
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CF594 goat anti-guinea pig IgG(H+L) |
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| 9-20118 | Biotium |
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Description: Minimum order quantity: 1 unit of 1mg |
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CF633 goat anti-mouse IgG(H+L) |
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| 9-20120 | Biotium |
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Description: Minimum order quantity: 1 unit of 1mg |
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CF633 goat anti-mouse IgG(H+L), highly cross-adsorbed |
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| 9-20121 | Biotium |
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Description: Minimum order quantity: 1 unit of 1mg |
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CF633 goat anti-rabbit IgG(H+L) |
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| 9-20122 | Biotium |
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Description: Minimum order quantity: 1 unit of 1mg |
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CF633 goat anti-rabbit IgG(H+L), highly cross-adsorbed |
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| 9-20123 | Biotium |
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Description: Minimum order quantity: 1 unit of 1mg |
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CF633 donkey anti-mouse IgG(H+L), highly cross-adsorbed |
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| 9-20124 | Biotium |
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Description: Minimum order quantity: 1 unit of 1mg |
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CF633 donkey anti-rabbit IgG(H+L), highly cross-adsorbed |
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| 9-20125 | Biotium |
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Description: Minimum order quantity: 1 unit of 1mg |
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CF633 goat anti-chicken IgY (IgG) (H+L), highly cross-adsorbed |
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| 9-20126 | Biotium |
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Description: Minimum order quantity: 1 unit of 1mg |
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CF633 donkey anti-goat IgG(H+L), highly cross-adsorbed |
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| 9-20127 | Biotium |
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Description: Minimum order quantity: 1 unit of 1mg |
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CF633 rabbit anti-goat IgG(H+L) |
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| 9-20128 | Biotium |
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Description: Minimum order quantity: 1 unit of 1mg |
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CF633 goat anti-guinea pig IgG(H+L) |
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| 9-20129 | Biotium |
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Description: Minimum order quantity: 1 unit of 1mg |
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CF633 goat anti-human IgG(H+L), highly cross-adsorbed |
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| 9-20132 | Biotium |
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Description: Minimum order quantity: 1 unit of 1mg |
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CF633 goat anti-rat IgG(H+L), highly cross-adsorbed |
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| 9-20133 | Biotium |
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Description: Minimum order quantity: 1 unit of 1mg |
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CF633 donkey anti-sheep IgG(H+L), highly cross-adsorbed |
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| 9-20134 | Biotium |
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Description: Minimum order quantity: 1 unit of 1mg |
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CF633 rabbit anti-rat IgG(H+L), highly cross-adsorbed |
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| 9-20135 | Biotium |
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Description: Minimum order quantity: 1 unit of 1mg |
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CF633 rabbit anti-mouse IgG(H+L), highly cross-adsorbed |
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| 9-20136 | Biotium |
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Description: Minimum order quantity: 1 unit of 1mg |
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CF633 donkey anti-rat IgG(H+L), highly cross-adsorbed |
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| 9-20137 | Biotium |
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Description: Minimum order quantity: 1 unit of 1mg |
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CF633 goat anti-swine IgG(H+L) |
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| 9-20138 | Biotium |
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Description: Minimum order quantity: 1 unit of 1mg |
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CF350 goat anti-mouse IgG(H+L) |
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| 9-20140 | Biotium |
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Description: Minimum order quantity: 1 unit of 1mg |
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CF350 goat anti-rabbit IgG(H+L) |
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| 9-20141 | Biotium |
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Description: Minimum order quantity: 1 unit of 1mg |
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CF350 donkey anti-goat IgG(H+L), highly cross-adsorbed |
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| 9-20142 | Biotium |
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Description: Minimum order quantity: 1 unit of 1mg |
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CF350 goat anti-mouse IgG(H+L), highly cross-adsorbed |
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| 9-20143 | Biotium |
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Description: Minimum order quantity: 1 unit of 1mg |
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CF350 goat anti-rabbit IgG(H+L), highly cross-adsorbed |
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| 9-20144 | Biotium |
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Description: Minimum order quantity: 1 unit of 1mg |
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CF350 goat anti-rat IgG(H+L), highly cross-adsorbed |
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| 9-20147 | Biotium |
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Description: Minimum order quantity: 1 unit of 1mg |
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CF350 donkey anti-sheep IgG(H+L), highly cross-adsorbed |
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| 9-20148 | Biotium |
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Description: Minimum order quantity: 1 unit of 1mg |
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CF350 rabbit anti-mouse IgG(H+L), highly cross-adsorbed |
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| 9-20149 | Biotium |
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Description: Minimum order quantity: 1 unit of 1mg |
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CF594 donkey anti-rabbit IgG(H+L), highly cross-adsorbed |
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| 9-20152 | Biotium |
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Description: Minimum order quantity: 1 unit of 1mg |
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CF594 goat anti-human IgG(H+L), highly cross-adsorbed |
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| 9-20154 | Biotium |
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Description: Minimum order quantity: 1 unit of 1mg |
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CF594 goat anti-rat IgG(H+L), highly cross-adsorbed |
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| 9-20155 | Biotium |
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Description: Minimum order quantity: 1 unit of 1mg |
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CF594 donkey anti-sheep IgG(H+L), highly cross-adsorbed |
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| 9-20156 | Biotium |
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Description: Minimum order quantity: 1 unit of 1mg |
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CF594 rabbit anti-rat IgG(H+L), highly cross-adsorbed |
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| 9-20157 | Biotium |
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Description: Minimum order quantity: 1 unit of 1mg |
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CF594 rabbit anti-mouse IgG(H+L), highly cross-adsorbed |
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| 9-20158 | Biotium |
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Description: Minimum order quantity: 1 unit of 1mg |
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CF594 donkey anti-rat IgG(H+L), highly cross-adsorbed |
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| 9-20159 | Biotium |
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Description: Minimum order quantity: 1 unit of 1mg |
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CF594 goat anti-swine IgG(H+L) |
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| 9-20160 | Biotium |
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Description: Minimum order quantity: 1 unit of 1mg |
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CF594 rabbit anti-chicken IgY ( IgG) (H+L) |
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| 9-20164 | Biotium |
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Description: Minimum order quantity: 1 unit of 1mg |
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CF633 rabbit anti-chicken IgY (IgG) (H+L) |
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| 9-20165 | Biotium |
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Description: Minimum order quantity: 1 unit of 1mg |
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CF488A donkey anti-chicken IgY (IgG) (H+L), highly cross-adsorbed |
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| 9-20166 | Biotium |
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Description: Minimum order quantity: 1 unit of 1mg |
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CF594 donkey anti-chicken IgY (IgG) (H+L), highly cross-adsorbed |
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| 9-20167 | Biotium |
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Description: Minimum order quantity: 1 unit of 1mg |
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CF633 donkey anti-chicken IgY (IgG) (H+L), highly cross-adsorbed |
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| 9-20168 | Biotium |
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Description: Minimum order quantity: 1 unit of 1mg |
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CF488A donkey anti-guinea pig IgG(H+L), highly cross-adsorbed |
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| 9-20169 | Biotium |
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Description: Minimum order quantity: 1 unit of 1mg |
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CF594 donkey anti-guinea pig IgG(H+L), highly cross-adsorbed |
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| 9-20170 | Biotium |
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Description: Minimum order quantity: 1 unit of 1mg |
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CF633 donkey anti-guinea pig IgG(H+L), highly cross-adsorbed |
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| 9-20171 | Biotium |
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Description: Minimum order quantity: 1 unit of 1mg |
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CF488A rabbit anti-sheep IgG(H+L), highly cross-adsorbed |
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| 9-20172 | Biotium |
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Description: Minimum order quantity: 1 unit of 1mg |
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CF594 rabbit anti-sheep IgG(H+L), highly cross-adsorbed |
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| 9-20173 | Biotium |
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Description: Minimum order quantity: 1 unit of 1mg |
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CF594 rabbit anti-sheep IgG(H+L), highly cross-adsorbed |
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| 9-20174 | Biotium |
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Description: Minimum order quantity: 1 unit of 1mg |
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CF640R goat anti-mouse IgG(H+L), highly cross-adsorbed |
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| 9-20175 | Biotium |
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Description: Minimum order quantity: 1 unit of 1mg |
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CF640R goat anti-rabbit IgG(H+L), highly cross-adsorbed |
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| 9-20176 | Biotium |
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Description: Minimum order quantity: 1 unit of 1mg |
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CF640R donkey anti-mouse IgG(H+L), highly cross-adsorbed |
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| 9-20177 | Biotium |
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Description: Minimum order quantity: 1 unit of 1mg |
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CF640R donkey anti-rabbit IgG(H+L), highly cross-adsorbed |
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| 9-20178 | Biotium |
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Description: Minimum order quantity: 1 unit of 1mg |
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CF640R donkey anti-goat IgG(H+L), highly cross-adsorbed |
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| 9-20179 | Biotium |
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Description: Minimum order quantity: 1 unit of 1mg |
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CF405M goat anti-mouse IgG(H+L) |
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| 9-20180 | Biotium |
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Description: Minimum order quantity: 1 unit of 1mg |
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CF405M goat anti-rabbit IgG(H+L) |
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| 9-20181 | Biotium |
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Description: Minimum order quantity: 1 unit of 1mg |
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CF405M goat anti-mouse IgG(H+L), highly cross-adsorbed |
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| 9-20182 | Biotium |
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Description: Minimum order quantity: 1 unit of 1mg |
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Biotin goat anti-mouse IgG(H+L) |
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| 9-20183 | Biotium |
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Description: Minimum order quantity: 1 unit of 1mg |
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Biotin goat anti-mouse IgG(H+L), highly cross-adsorbed |
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| 9-20184 | Biotium |
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Description: Minimum order quantity: 1 unit of 1mg |
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Biotin goat anti-rabbit IgG(H+L) |
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| 9-20185 | Biotium |
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Description: Minimum order quantity: 1 unit of 1mg |
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Biotin goat anti-rabbit IgG(H+L), highly cross-adsorbed |
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| 9-20186 | Biotium |
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Description: Minimum order quantity: 1 unit of 1mg |
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Biotin donkey anti-goat IgG(H+L), highly cross-adsorbed |
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| 9-20189 | Biotium |
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Description: Minimum order quantity: 1 unit of 1mg |
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Biotin donkey anti-mouse IgG(H+L), highly cross-adsorbed |
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| 9-20190 | Biotium |
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Description: Minimum order quantity: 1 unit of 1mg |
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Biotin donkey anti-rabbit IgG(H+L), highly cross-adsorbed |
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| 9-20191 | Biotium |
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Description: Minimum order quantity: 1 unit of 1mg |
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CF640R goat anti-mouse IgG(H+L) |
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| 9-20197 | Biotium |
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Description: Minimum order quantity: 1 unit of 1mg |
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CF350 goat anti-guinea pig IgG(H+L) |
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| 9-20198 | Biotium |
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Description: Minimum order quantity: 1 unit of 1mg |
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CF640R donkey anti-rat IgG(H+L), highly cross-adsorbed |
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| 9-20199 | Biotium |
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Description: Minimum order quantity: 1 unit of 1mg |
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CF640R rabbit anti-mouseIgG(H+L), highly cross-adsorbed |
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| 9-20200 | Biotium |
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Description: Minimum order quantity: 1 unit of 1mg |
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CF640R rabbit anti-rat IgG(H+L), highly cross-adsorbed |
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| 9-20201 | Biotium |
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Description: Minimum order quantity: 1 unit of 1mg |
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CF640R goat anti-rabbit IgG(H+L) |
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| 9-20202 | Biotium |
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Description: Minimum order quantity: 1 unit of 1mg |
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CF488A chicken anti-mouse IgG(H+L) |
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| 9-20208 | Biotium |
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Description: Minimum order quantity: 1 unit of 1mg |
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CF488A chicken anti-rabbit IgG(H+L) |
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| 9-20209 | Biotium |
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Description: Minimum order quantity: 1 unit of 1mg |
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CF594 chicken anti-mouse IgG(H+L) |
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| 9-20221 | Biotium |
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Description: Minimum order quantity: 1 unit of 1mg |
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CF633 chicken anti-mouse IgG(H+L) |
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| 9-20222 | Biotium |
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Description: Minimum order quantity: 1 unit of 1mg |
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CF594 chicken anti-rabbit IgG(H+L) |
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| 9-20223 | Biotium |
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Description: Minimum order quantity: 1 unit of 1mg |
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CF633 chicken anti-rabbit IgG(H+L) |
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| 9-20224 | Biotium |
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Description: Minimum order quantity: 1 unit of 1mg |
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CF488A chicken anti-goat IgG(H+L) |
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| 9-20225 | Biotium |
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Description: Minimum order quantity: 1 unit of 1mg |
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CF594 chicken anti-goat IgG(H+L) |
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| 9-20226 | Biotium |
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Description: Minimum order quantity: 1 unit of 1mg |
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CF633 chicken anti-goat IgG(H+L) |
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| 9-20227 | Biotium |
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Description: Minimum order quantity: 1 unit of 1mg |
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CF555 goat anti-human IgG(H+L), highly cross-adsorbed |
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| 9-20230 | Biotium |
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Description: Minimum order quantity: 1 unit of 1mg |
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CF555 goat anti-mouse IgG(H+L), highly cross-adsorbed |
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| 9-20231 | Biotium |
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Description: Minimum order quantity: 1 unit of 1mg |
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CF555 goat anti-rabbit IgG(H+L), highly cross-adsorbed |
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| 9-20232 | Biotium |
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Description: Minimum order quantity: 1 unit of 1mg |
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CF555 goat anti-rat IgG(H+L), highly cross-adsorbed |
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| 9-20233 | Biotium |
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Description: Minimum order quantity: 1 unit of 1mg |
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CF555 donkey anti-sheep IgG(H+L), highly cross-adsorbed |
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| 9-20234 | Biotium |
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Description: Minimum order quantity: 1 unit of 1mg |
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CF555 rabbit anti-mouse IgG(H+L), highly cross-adsorbed |
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| 9-20235 | Biotium |
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Description: Minimum order quantity: 1 unit of 1mg |
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CF555 goat anti-swine IgG(H+L) |
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| 9-20236 | Biotium |
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Description: Minimum order quantity: 1 unit of 1mg |
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CF680 rabbit anti-guinea pig IgG(H+L) |
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| 9-20243 | Biotium |
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Description: Minimum order quantity: 1 unit of 1mg |
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CF770 rabbit anti-guinea pig IgG(H+L) |
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| 9-20244 | Biotium |
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Description: Minimum order quantity: 1 unit of 1mg |
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CF350 donkey anti-chicken IgY (IgG) (H+L), highly cross-adsorbed |
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| 9-20275 | Biotium |
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Description: Minimum order quantity: 1 unit of 1mg |
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CF555 donkey anti-guinea pig IgG (H+L), highly cross-adsorbed |
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| 9-20276 | Biotium |
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Description: Minimum order quantity: 1 unit of 1mg |
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CF647 goat anti-human IgG(H+L), highly cross-adsorbed |
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| 9-20280 | Biotium |
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Description: Minimum order quantity: 1 unit of 1mg |
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CF647 goat anti-mouse IgG(H+L), highly cross-adsorbed |
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| 9-20281 | Biotium |
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Description: Minimum order quantity: 1 unit of 1mg |
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CF647 goat anti-rabbit IgG(H+L), highly cross-adsorbed |
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| 9-20282 | Biotium |
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Description: Minimum order quantity: 1 unit of 1mg |
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CF647 goat anti-rat IgG(H+L), highly cross-adsorbed |
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| 9-20283 | Biotium |
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Description: Minimum order quantity: 1 unit of 1mg |
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CF647 donkey anti-sheep IgG(H+L), highly cross-adsorbed |
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| 9-20284 | Biotium |
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Description: Minimum order quantity: 1 unit of 1mg |
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CF647 rabbit anti-mouse IgG(H+L), highly cross-adsorbed |
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| 9-20285 | Biotium |
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Description: Minimum order quantity: 1 unit of 1mg |
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CF647 goat anti-swine IgG(H+L) |
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| 9-20286 | Biotium |
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|
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Description: Minimum order quantity: 1 unit of 1mg |
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CF488A Bovine anti-goat IgG(H+L), highly cross-adsorbed |
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| 9-20293 | Biotium |
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Description: Minimum order quantity: 1 unit of 1mg |
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CF568 Bovine anti-goat IgG(H+L), highly cross-adsorbed |
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| 9-20294 | Biotium |
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|
|
Description: Minimum order quantity: 1 unit of 1mg |
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CF594 Bovine anti-goat IgG(H+L), highly cross-adsorbed |
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| 9-20295 | Biotium |
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|
|
Description: Minimum order quantity: 1 unit of 1mg |
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CF633 Bovine anti-goat IgG(H+L), highly cross-adsorbed |
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| 9-20296 | Biotium |
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|
|
Description: Minimum order quantity: 1 unit of 1mg |
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CF640R Bovine anti-goat IgG(H+L), highly cross-adsorbed |
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| 9-20297 | Biotium |
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|
|
Description: Minimum order quantity: 1 unit of 1mg |
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CF543 Goat anti-mouse IgG (H+L), highly cross-adsorbed |
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| 9-20299 | Biotium |
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|
|
Description: Minimum order quantity: 1 unit of 1mg |
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CF543 Goat anti-rabbit IgG (H+L), highly cross-adsorbed |
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| 9-20300 | Biotium |
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|
|
Description: Minimum order quantity: 1 unit of 1mg |
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CF568 Goat anti-mouse IgG (H+L), highly cross-adsorbed (min X Rat) |
|||
| 9-20301 | Biotium |
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|
|
Description: Minimum order quantity: 1 unit of 1mg |
|||
CF488A Goat anti-mouse IgG (H+L), highly cross-adsorbed (min X Rat) |
|||
| 9-20302 | Biotium |
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|
|
Description: Minimum order quantity: 1 unit of 1mg |
|||
CF594 Goat anti-mouse IgG (H+L), highly cross-adsorbed (min X Rat) |
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| 9-20303 | Biotium |
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|
|
Description: Minimum order quantity: 1 unit of 1mg |
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CF640R Goat anti-mouse IgG (H+L), highly cross-adsorbed (min X Rat) |
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| 9-20304 | Biotium |
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|
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Description: Minimum order quantity: 1 unit of 1mg |
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CF543 Donkey anti-mouse IgG(H+L), highly cross-adsorbed |
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| 9-20305 | Biotium |
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Description: Minimum order quantity: 1 unit of 1mg |
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CF543 goat anti-mouse IgG(H+L) |
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| 9-20306 | Biotium |
|
|
|
Description: Minimum order quantity: 1 unit of 1mg |
|||
CF543 Rabbit anti-mouse IgG(H+L), highly cross-adsorbed |
|||
| 9-20307 | Biotium |
|
|
|
Description: Minimum order quantity: 1 unit of 1mg |
|||
CF543 Donkey anti-rabbit IgG(H+L), highly cross-adsorbed |
|||
| 9-20308 | Biotium |
|
|
|
Description: Minimum order quantity: 1 unit of 1mg |
|||
CF543 goat anti-rabbit IgG(H+L) |
|||
| 9-20309 | Biotium |
|
|
|
Description: Minimum order quantity: 1 unit of 1mg |
|||
CF543 donkey anti-chicken IgY (IgG) (H+L), highly cross-adsorbed |
|||
| 9-20310 | Biotium |
|
|
|
Description: Minimum order quantity: 1 unit of 1mg |
|||
CF543 goat anti-chicken IgY(H+L), highly cross-adsorbed |
|||
| 9-20311 | Biotium |
|
|
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Description: Minimum order quantity: 1 unit of 1mg |
|||
CF543 rabbit anti-chicken IgY (IgG) (H+L) |
|||
| 9-20312 | Biotium |
|
|
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Description: Minimum order quantity: 1 unit of 1mg |
|||
CF543 Bovine anti-goat IgG(H+L), highly cross-adsorbed |
|||
| 9-20313 | Biotium |
|
|
|
Description: Minimum order quantity: 1 unit of 1mg |
|||
CF543 Donkey anti-goat IgG(H+L), highly cross-adsorbed |
|||
| 9-20314 | Biotium |
|
|
|
Description: Minimum order quantity: 1 unit of 1mg |
|||
CF543 rabbit anti-goat IgG(H+L) |
|||
| 9-20315 | Biotium |
|
|
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Description: Minimum order quantity: 1 unit of 1mg |
|||
CF543 donkey anti-guinea pig IgG (H+L), highly cross-adsorbed |
|||
| 9-20316 | Biotium |
|
|
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Description: Minimum order quantity: 1 unit of 1mg |
|||
CF543 goat anti-guinea pig IgG(H+L) |
|||
| 9-20317 | Biotium |
|
|
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Description: Minimum order quantity: 1 unit of 1mg |
|||
CF543 donkey anti-human IgG(H+L), highly cross-adsorbed |
|||
| 9-20318 | Biotium |
|
|
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Description: Minimum order quantity: 1 unit of 1mg |
|||
CF543 goat anti-human IgG(H+L), highly cross-adsorbed |
|||
| 9-20319 | Biotium |
|
|
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Description: Minimum order quantity: 1 unit of 1mg |
|||
CF543 donkey anti-rat IgG(H+L), highly cross-adsorbed |
|||
| 9-20320 | Biotium |
|
|
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Description: Minimum order quantity: 1 unit of 1mg |
|||
CF543 goat anti-rat IgG(H+L), highly cross-adsorbed |
|||
| 9-20321 | Biotium |
|
|
|
Description: Minimum order quantity: 1 unit of 1mg |
|||
CF543 donkey anti-sheep IgG(H+L), highly cross-adsorbed |
|||
| 9-20322 | Biotium |
|
|
|
Description: Minimum order quantity: 1 unit of 1mg |
|||
CF543 rabbit anti-sheep IgG(H+L), highly cross-adsorbed |
|||
| 9-20323 | Biotium |
|
|
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Description: Minimum order quantity: 1 unit of 1mg |
|||
CF543 goat anti-swine IgG(H+L) |
|||
| 9-20324 | Biotium |
|
|
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Description: Minimum order quantity: 1 unit of 1mg |
|||
CF543 Goat anti-mouse IgG (H+L), highly cross-adsorbed (min X Rat) |
|||
| 9-20328 | Biotium |
|
|
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Description: Minimum order quantity: 1 unit of 1mg |
|||
CF350 Chicken Anti-Mouse IgG(H+L), 2 mg/mL |
|||
| 9-20331 | Biotium |
|
|
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Description: Minimum order quantity: 1 unit of 50uL |
|||
CF350 Chicken Anti-Rabbit IgG(H+L), 2 mg/mL |
|||
| 9-20332 | Biotium |
|
|
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Description: Minimum order quantity: 1 unit of 50uL |
|||
CF543 Chicken Anti-Goat IgG(H+L), 2 mg/mL |
|||
| 9-20333 | Biotium |
|
|
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Description: Minimum order quantity: 1 unit of 50uL |
|||
CF543 Chicken Anti-Mouse IgG(H+L), 2 mg/mL |
|||
| 9-20334 | Biotium |
|
|
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Description: Minimum order quantity: 1 unit of 50uL |
|||
CF543 Chicken Anti-Rabbit IgG(H+L), 2 mg/mL |
|||
| 9-20335 | Biotium |
|
|
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Description: Minimum order quantity: 1 unit of 50uL |
|||
CF543 Rabbit Anit-Guinea Pig IgG(H+L), 2 mg/mL |
|||
| 9-20336 | Biotium |
|
|
|
Description: Minimum order quantity: 1 unit of 50uL |
|||
CF568 Chicken Anti-Goat IgG(H+L), 2 mg/mL |
|||
| 9-20337 | Biotium |
|
|
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Description: Minimum order quantity: 1 unit of 50uL |
|||
CF568 Chicken Anti-Mouse IgG(H+L), 2 mg/mL |
|||
| 9-20338 | Biotium |
|
|
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Description: Minimum order quantity: 1 unit of 50uL |
|||
CF568 Chicken Anti-Rabbit IgG(H+L), 2 mg/mL |
|||
| 9-20339 | Biotium |
|
|
|
Description: Minimum order quantity: 1 unit of 50uL |
|||
CF405M Goat anti-mouse IgG (H+L), highly cross-adsorbed (min X Rat), 2 mg/mL |
|||
| 9-20340 | Biotium |
|
|
|
Description: Minimum order quantity: 1 unit of 50uL |
|||
CF633 Goat anti-mouse IgG (H+L), highly cross-adsorbed (min X Rat), 2 mg/mL |
|||
| 9-20341 | Biotium |
|
|
|
Description: Minimum order quantity: 1 unit of 50uL |
|||
CF647 Goat Anti-Human IgM (mu chain), 2mg/mL |
|||
| 9-20346 | Biotium |
|
|
|
Description: Minimum order quantity: 1 unit of 50uL |
|||
CF488A Goat Anti-Human IgM (mu chain), 2mg/mL |
|||
| 9-20347 | Biotium |
|
|
|
Description: Minimum order quantity: 1 unit of 50uL |
|||
CF594 Goat Anti-Human IgM (mu chain), 2mg/mL |
|||
| 9-20348 | Biotium |
|
|
|
Description: Minimum order quantity: 1 unit of 50uL |
|||
CF640R Goat Anti-Human IgM (mu chain), 2mg/mL |
|||
| 9-20349 | Biotium |
|
|
|
Description: Minimum order quantity: 1 unit of 50uL |
|||
CF350 Donkey anti-mouse IgG(H+L), highly cross-adsorbed |
|||
| 9-20350 | Biotium |
|
|
|
Description: Minimum order quantity: 1 unit of 1mg |
|||
CF350 Donkey anti-rabbit IgG(H+L), highly cross-adsorbed |
|||
| 9-20351 | Biotium |
|
|
|
Description: Minimum order quantity: 1 unit of 1mg |
|||
R-phycoerythrin goat anti-mouse IgG(H+L), 0.5 mg/mL |
|||
| 9-20352 | Biotium |
|
|
|
Description: Minimum order quantity: 1 unit of 200uL |
|||
R-phycoerythrin goat anti-rabbit IgG(H+L), 0.5 mg/mL |
|||
| 9-20353 | Biotium |
|
|
|
Description: Minimum order quantity: 1 unit of 200uL |
|||
R-phycoerythrin goat anti-rat IgG(H+L), highly cross-adsorbed, 0.5 mg/mL |
|||
| 9-20354 | Biotium |
|
|
|
Description: Minimum order quantity: 1 unit of 200uL |
|||
R-phycoerythrin goat anti-human IgG(H+L), highly cross-adsorbed, 0.5 mg/mL |
|||
| 9-20355 | Biotium |
|
|
|
Description: Minimum order quantity: 1 unit of 200uL |
|||
CF405S Donkey anti-guinea pig IgG(H+L), highly cross-adsorbed, 2 mg/mL |
|||
| 9-20356 | Biotium |
|
|
|
Description: Minimum order quantity: 1 unit of 50uL |
|||
Genetic analysis of youngsters with congenital ocular anomalies in three ecological areas of Nepal: a piece II of Nepal pediatric ocular diseases analysis
Background: Genetic eye diseases characterize a giant and heterogeneous group of childhood ocular morbidity. Explicit particular person diseases might set off quite a few structural anomalies and developmental choices.
Nepal Pediatric Ocular Sickness Analysis (NPODS) was a population-based epidemiological analysis carried out all through three ecological areas of Nepal to seek out out the prevalence and etiology of childhood ocular morbidity and blindness. In Half II of this analysis, genetic analysis was carried out for youths who’ve been found to have congenital ocular anomalies.
Methodology: It was a cross sectional descriptive analysis. An entire of 10,270 kids all through three completely totally different ecological areas in Nepal (Low lands, hills, and mountains) underwent ocular examinations in NPODS.
Out of 374 (3.6%) of youngsters with ocular abnormalities, 30 have been thought of congenital in nature. Centered genetic analysis, along with genotyping for genes specific to presenting phenotype, was carried out for 25 kids using serum samples.
Outcomes: Out of 25 kids, 18 had vital genetic outcomes. Analysis revealed one missense alteration G12411T of Zinc Finger Homeobox 4 (ZFHX4) gene in a single participant amongst 10 with congenital ptosis and one different missense variation T > C P. Y374 C of Signaling Receptor and Transporter Retinol 6 (STRA6) gene in a single participant amongst Three with microphthalmos.
Conclusion: The analysis is first of its type from Nepal and mutant genes have been distinctive to Nepalese Inhabitants. Further analysis of genetic parts is important to greater understand genetic affiliation with ocular diseases and conditions. This helps further in genetic counseling and probably gene treatment to forestall blindness from these conditions.
Subsequent era sequencing reveals a novel pathogenic variant within the ATMgene
Introduction: Ataxia telangiectasia (A-T) is a unusual autosomal recessive multisystemic sickness. Victims with the A-T syndrome present a broad spectrum of sickness phenotypes. The ATM (ataxia telangiectasia mutated) gene, the one causative gene for A-T.
Methodology: A affected particular person of Persian origin presenting with typical A-T was referred to our genetics center for specialised genetic counseling and testing. Centered next-generation sequencing (NGS) was utilized.
Sanger sequencing was used to substantiate the candidate variant. Modeling was carried out using the SWISS-MODEL server.Outcomes: A homozygous stop-gain variant c.829G > T (p.E277*) was found throughout the ATM gene. This variant was confirmed by Sanger sequencing and modeling of native development and truncated development was carried out.
Conclusion: To this point, just a few pathogenic variants of the ATM gene have been reported from the Iranian inhabitants. The discovering has implications in molecular diagnostic for A-T in Iran.
Familial dilated cardiomyopathy introduced on by a novel variant throughout the Lamin A/C gene: a case report
Background: Familial dilated cardiomyopathy (FDCM) is usually inherited as an autosomal dominant trait. The Lamin A/C (LMNA) gene variants have been acknowledged to be associated to DCM, conductive system issues, form 2 Emery-Dreifuss muscular dystrophy and quite a few different totally different issues. Proper right here, we reported a novel variant throughout the LMNA gene that’s more likely to be related to FDCM.
Case presentation: A 30-year-old youthful man was hospitalized for chest tightness, extreme fatigue, palpitation and impaired train tolerance. He had scientific traits along with cardiac dilatation, atrial tachyarrhythmia, excessive conductive system issues, and dyskinesia of every greater limbs and the neck. Genetic sequence analysis indicated that the affected particular person carried a novel c.1325 T>C heterozygous LMNA gene variant. Catheter ablation and cardiac resynchronization treatment with pacing carry out (CRT-P) have been carried out to take care of the arrhythmia.
Conclusion: The variant c.1325 T>C is a novel variant throughout the LMNA gene that has not been beforehand reported. Youthful victims with DCM, conductive system issues and skeletal myopathy should be alert to the potential for LMNA gene variant. Cardiac resynchronization treatment (CRT) may be an reasonably priced choice for affected particular person carrying a LMNA gene variant with third-degree atrioventricular block even when the left ventricular ejection fraction is preserved with the intention to cease the deterioration of cardiac carry out introduced on by correct ventricular pacing dependency.
Doxorubicin hydrochloride |
|||
| GA4969-100MG | Glentham Life Sciences | 100 mg | EUR 217.2 |
Doxorubicin hydrochloride |
|||
| GA4969-10MG | Glentham Life Sciences | 10 mg | EUR 93.6 |
Doxorubicin hydrochloride |
|||
| GA4969-25MG | Glentham Life Sciences | 25 mg | EUR 117.6 |
Doxorubicin hydrochloride |
|||
| GA4969-50MG | Glentham Life Sciences | 50 mg | EUR 151.2 |
Doxorubicin (hydrochloride) |
|||
| HY-15142 | MedChemExpress | 100mg | EUR 176.4 |
Doxorubicin hydrochloride |
|||
| TNC00267 | ChemNorm | 20mg | Ask for price |
Doxorubicin hydrochloride USP |
|||
| D005-10MG | TOKU-E | 10 mg | EUR 199.2 |
Doxorubicin hydrochloride USP |
|||
| D005-25MG | TOKU-E | 25 mg | EUR 361.2 |
Doxorubicin Hydrochloride (Autophagy inducer) |
|||
| SIH-390-10MG | Stressmarq | 10 mg | EUR 231.6 |
|
Description: The substance Doxorubicin Hydrochloride is a autophagy inducer. It is synthetically produced and has a purity of >98%. The pure substance is red solid which is soluble in water (50 mM).. |
|||
Doxorubicin Hydrochloride (Autophagy inducer) |
|||
| SIH-390-50MG | Stressmarq | 50 mg | EUR 634.8 |
|
Description: The substance Doxorubicin Hydrochloride is a autophagy inducer. It is synthetically produced and has a purity of >98%. The pure substance is red solid which is soluble in water (50 mM).. |
|||
Erlotinib, Hydrochloride Salt |
|||
| 1588-100 | Biovision | EUR 202.8 | |
Erlotinib, Hydrochloride Salt |
|||
| 1588-1000 | Biovision | EUR 477.6 | |
Doxorubicin |
|||
| A3966-10 | ApexBio | 10 mg | EUR 129.6 |
|
Description: Doxorubicin is a semi-synthesized anticancer agent derived from bacterial culture. [1] It is an anthracycline antibiotic. It is been widely used in blood cancers, solid tumors and sarcomas. |
|||
Doxorubicin |
|||
| A3966-100 | ApexBio | 100 mg | EUR 282 |
|
Description: Doxorubicin is a semi-synthesized anticancer agent derived from bacterial culture. [1] It is an anthracycline antibiotic. It is been widely used in blood cancers, solid tumors and sarcomas. |
|||
Doxorubicin |
|||
| A3966-25 | ApexBio | 25 mg | EUR 157.2 |
|
Description: Doxorubicin is a semi-synthesized anticancer agent derived from bacterial culture. [1] It is an anthracycline antibiotic. It is been widely used in blood cancers, solid tumors and sarcomas. |
|||
Doxorubicin |
|||
| A3966-5.1 | ApexBio | 10 mM (in 1mL DMSO) | EUR 157.2 |
|
Description: Doxorubicin is a semi-synthesized anticancer agent derived from bacterial culture. [1] It is an anthracycline antibiotic. It is been widely used in blood cancers, solid tumors and sarcomas. |
|||
Doxorubicin |
|||
| A3966-S | ApexBio | Evaluation Sample | EUR 97.2 |
|
Description: Doxorubicin is a semi-synthesized anticancer agent derived from bacterial culture. [1] It is an anthracycline antibiotic. It is been widely used in blood cancers, solid tumors and sarcomas. |
|||
Doxorubicin |
|||
| D063-100MG | TOKU-E | 100 mg | EUR 1261.2 |
Doxorubicin |
|||
| D063-25MG | TOKU-E | 25 mg | EUR 386.4 |
Doxorubicin |
|||
| ADC-P-013 | Creative Biolabs | unit | Ask for price |
Doxorubicin |
|||
| abx188695-1g | Abbexa | 1 g | EUR 560.4 |
Doxorubicin |
|||
| HY-15142A | MedChemExpress | 100mg | EUR 258 |
Erlotinib, Hydrochloride Salt, >99% |
|||
| BC026-101 | GenDepot | 1g | EUR 327.6 |
Erlotinib, Hydrochloride Salt, >99% |
|||
| BC026-102 | GenDepot | 2g | EUR 465.6 |
Erlotinib, Hydrochloride Salt, >99% |
|||
| BC026-105 | GenDepot | 5g | EUR 684 |
17-DMAG, Hydrochloride Salt, >98% |
|||
| BC024-001 | GenDepot | 1mg | EUR 213.6 |
17-DMAG, Hydrochloride Salt, >98% |
|||
| BC024-005 | GenDepot | 5mg | EUR 343.2 |
17-DMAG, Hydrochloride Salt, >98% |
|||
| BC024-010 | GenDepot | 10mg | EUR 489.6 |
17-DMAG, Hydrochloride Salt, >98% |
|||
| BC024-025 | GenDepot | 25mg | Ask for price |
17-DMAG, Hydrochloride Salt, >99% |
|||
| BC024-100 | GenDepot | 100mg | Ask for price |
17-DMAG, Hydrochloride Salt, >99% |
|||
| BC024-101 | GenDepot | 1g | Ask for price |
17-DMAG, Hydrochloride Salt, >99% |
|||
| BC024-250 | GenDepot | 250mg | Ask for price |
OSU-03012, Hydrochloride Salt, >98% |
|||
| BC061-005 | GenDepot | 5mg | EUR 375.6 |
OSU-03012, Hydrochloride Salt, >98% |
|||
| BC061-025 | GenDepot | 25mg | EUR 634.8 |
Adriamycin (Doxorubicin) |
|||
| E1KS1208 | EnoGene | 10mg | EUR 490.8 |
Doxorubicin HCl |
|||
| 20-abx184016 | Abbexa |
|
|
Doxorubicin 10mM |
|||
| TG4120 | TopoGen | 0.25ml | EUR 187.2 |
Doxorubicin (Adriamycin) HCl |
|||
| A1832-10 | ApexBio | 10 mg | EUR 150 |
|
Description: Doxorubicin is a semi-synthesized anticancer agent derived from bacterial culture. [1] It is an anthracycline antibiotic. It is been widely used in blood cancers, solid tumors and sarcomas. |
|||
Doxorubicin (Adriamycin) HCl |
|||
| A1832-100 | ApexBio | 100 mg | EUR 560.4 |
|
Description: Doxorubicin is a semi-synthesized anticancer agent derived from bacterial culture. [1] It is an anthracycline antibiotic. It is been widely used in blood cancers, solid tumors and sarcomas. |
|||
Doxorubicin (Adriamycin) HCl |
|||
| A1832-25 | ApexBio | 25 mg | EUR 226.8 |
|
Description: Doxorubicin is a semi-synthesized anticancer agent derived from bacterial culture. [1] It is an anthracycline antibiotic. It is been widely used in blood cancers, solid tumors and sarcomas. |
|||
Doxorubicin (Adriamycin) HCl |
|||
| A1832-5.1 | ApexBio | 10 mM (in 1mL DMSO) | EUR 135.6 |
|
Description: Doxorubicin is a semi-synthesized anticancer agent derived from bacterial culture. [1] It is an anthracycline antibiotic. It is been widely used in blood cancers, solid tumors and sarcomas. |
|||
Doxorubicin HCl, 100mg |
|||
| R2531-100mg | ACTGene | EUR 1560 | |
Doxorubicin HCl, 10mg |
|||
| R2531-10mg | ACTGene | EUR 236.4 | |
Anti-EGFR-doxorubicin ADC |
|||
| ADC-W-600 | Creative Biolabs | 1mg | Ask for price |
|
Description: This ADC product is comprised of an anti-EGFR monoclonal antibody conjugated via a linker to a doxorubicin |
|||
Anti-CD22-DIBO-doxorubicin ADC |
|||
| ADC-W-339 | Creative Biolabs | 1mg | Ask for price |
|
Description: This ADC product is comprised of an anti-CD22 monoclonal antibody conjugated via a DIBO linker to a doxorubicin |
|||
PEGylated Liposomal Doxorubicin- 2 mg |
|||
| PHPC002DX | ProFoldin | 2 mg | EUR 140.62 |
|
Description: This product includes 1 ml of liposomal doxorubicin at concentrations of 2 mg/ml doxorubicin and 16 mg/ml of lipids. |
|||
PEGylated Liposomal Doxorubicin- 20 mg |
|||
| PHPC020DX | ProFoldin | 20 mg | EUR 358.62 |
|
Description: This product includes 10 ml of liposomal doxorubicin at concentrations of 2 mg/ml doxorubicin and 16 mg/ml of lipids. |
|||
Anti-TNFRSF8 (cAC10)-DIBO-doxorubicin ADC |
|||
| ADC-W-406 | Creative Biolabs | 1mg | Ask for price |
|
Description: This ADC product is comprised of an anti-TNFRSF8 monoclonal antibody (cAC10) conjugated via a DIBO linker to a doxorubicin |
|||
Anti-ERBB2 (Trastuzumab)-NGM-doxorubicin ADC |
|||
| ADC-W-412 | Creative Biolabs | 1mg | Ask for price |
|
Description: This ADC product is comprised of an anti-ERBB2 monoclonal antibody conjugated via a NGM linker to adoxorubicin |
|||
Anti-EGFR (cetuximab)-SMCC-Doxorubicin ADC |
|||
| ADC-W-504 | Creative Biolabs | 1mg | Ask for price |
|
Description: This ADC product is comprised of an anti-EGFR monoclonal antibody (cetuximab) conjugated via a SMCC linker to Doxorubicin |
|||
Anti-EpCAM (MOC31)-hydrazone-Doxorubicin ADC |
|||
| ADC-W-581 | Creative Biolabs | 1mg | Ask for price |
|
Description: This ADC product is comprised of an anti-EPCAM monoclonal antibody (MOC31) conjugated via a hydrazone linker to Doxorubicin |
|||
Anti-FUT3 (clone cBR96)-hydrazone-doxorubicin ADC |
|||
| ADC-W-423 | Creative Biolabs | 1mg | Ask for price |
|
Description: This ADC product is comprised of an anti-FUT3 monoclonal antibody (clone cBR96) conjugated via a hydrazone linker to adoxorubicin |
|||
Anti-CD70 (clone h1F6)-β-glucuronide-doxorubicin ADC |
|||
| ADC-W-376 | Creative Biolabs | 1mg | Ask for price |
|
Description: This ADC product is comprised of an anti-CD70 monoclonal antibody (clone h1F6) conjugated via a β-glucuronide linker to a doxorubicin |
|||
Bile salt |
|||
| BB0225 | Bio Basic | 25g | EUR 95.5 |
Mannitol Salt |
|||
| 254027 | Scientific Laboratory Supplies | PK20 | EUR 13.68 |
Anti-TNFRSF8 (cCA10)-β-glucuronide-doxorubicin propyloxazoline (DPO) ADC |
|||
| ADC-W-353 | Creative Biolabs | 1mg | Ask for price |
|
Description: This ADC product is comprised of an anti-TNFRSF8 monoclonal antibody (cCA10) conjugated via a β-glucuronide linker to a doxorubicin propyloxazoline (DPO) |
|||
Human HeLa (Cervix Adenocarcinoma) Cell Nuclear Extract - Doxorubicin Stimulated |
|||
| HCL-2004 | Alpha Diagnostics | 100ug | EUR 270 |
Human HeLa (Cervix Adenocarcinoma) Whole Cell Lysate - Doxorubicin Stimulated |
|||
| HCL-2010 | Alpha Diagnostics | 100ug | EUR 255.6 |
Tetracycline, Hydrochloride |
|||
| CH054 | ABM | 25 g | EUR 142.8 |
Tetracycline, Hydrochloride |
|||
| CH055 | ABM | 100 g | EUR 204 |
Ciprofloxacin hydrochloride |
|||
| C032-25G | TOKU-E | 25 g | EUR 199.2 |
Ciprofloxacin hydrochloride |
|||
| C032-5G | TOKU-E | 5 g | EUR 74.4 |
Clindamycin Hydrochloride |
|||
| C035-100MG | TOKU-E | 100 mg | EUR 243.6 |
Clindamycin Hydrochloride |
|||
| C035-50MG | TOKU-E | 50 mg | EUR 152.4 |
Chlortetracycline Hydrochloride |
|||
| C072-100G | TOKU-E | 100 g | EUR 376.8 |
Chlortetracycline Hydrochloride |
|||
| C072-25G | TOKU-E | 25 g | EUR 157.2 |
Chlortetracycline Hydrochloride |
|||
| C072-5G | TOKU-E | 5 g | EUR 78 |
Cefozopran Hydrochloride |
|||
| C099-100MG | TOKU-E | 100 mg | EUR 300 |
Cysteamine hydrochloride |
|||
| C212-25G | TOKU-E | 25 g | EUR 78 |
Cysteamine hydrochloride |
|||
| C212-4x25G | TOKU-E | 4 x 25 g | EUR 154.8 |
Ceftiofur Hydrochloride |
|||
| C228-1G | TOKU-E | 1 g | EUR 129.6 |
Ceftiofur Hydrochloride |
|||
| C228-5G | TOKU-E | 5 g | EUR 387.6 |
Cefmenoxime Hydrochloride |
|||
| C240-100MG | TOKU-E | 100mg | EUR 136.8 |
Cefmenoxime Hydrochloride |
|||
| C240-500MG | TOKU-E | 500mg | EUR 334.8 |
Cinacalcet Hydrochloride |
|||
| C242-100MG | TOKU-E | 100mg | EUR 513.6 |
Cinacalcet Hydrochloride |
|||
| C242-10MG | TOKU-E | 10mg | EUR 94.8 |
Enrofloxacin hydrochloride |
|||
| E007-100MG | TOKU-E | 100 mg | EUR 147.6 |
Enrofloxacin hydrochloride |
|||
| E007-1G | TOKU-E | 1 g | EUR 776.4 |
Enrofloxacin hydrochloride |
|||
| E007-500MG | TOKU-E | 500 mg | EUR 475.2 |
Erlotinib hydrochloride |
|||
| E017-100MG | TOKU-E | 100 mg | EUR 136.8 |
Erlotinib hydrochloride |
|||
| E017-1G | TOKU-E | 1 g | EUR 373.2 |
Pazopanib Hydrochloride |
|||
| A8347-100 | ApexBio | 100 mg | EUR 268.8 |
|
Description: Pazopanib HCl is a receptor tyrosine kinase inhibitor that targets multiple kinases, including VEGFR1, VEGFR2, VEGFR3, PDGFR, FGFR, c-Kit, and c-Fms, with IC50s 10nM, 30nM, 47nM, 84nM, 74nM, 140nM, and 146nM respectively [1-3]. |
|||
Pazopanib Hydrochloride |
|||
| A8347-25 | ApexBio | 25 mg | EUR 129.6 |
|
Description: Pazopanib HCl is a receptor tyrosine kinase inhibitor that targets multiple kinases, including VEGFR1, VEGFR2, VEGFR3, PDGFR, FGFR, c-Kit, and c-Fms, with IC50s 10nM, 30nM, 47nM, 84nM, 74nM, 140nM, and 146nM respectively [1-3]. |
|||
Pazopanib Hydrochloride |
|||
| A8347-5.1 | ApexBio | 10 mM (in 1mL DMSO) | EUR 135.6 |
|
Description: Pazopanib HCl is a receptor tyrosine kinase inhibitor that targets multiple kinases, including VEGFR1, VEGFR2, VEGFR3, PDGFR, FGFR, c-Kit, and c-Fms, with IC50s 10nM, 30nM, 47nM, 84nM, 74nM, 140nM, and 146nM respectively [1-3]. |
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Pazopanib Hydrochloride |
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| A8347-500 | ApexBio | 500 mg | EUR 727.2 |
|
Description: Pazopanib HCl is a receptor tyrosine kinase inhibitor that targets multiple kinases, including VEGFR1, VEGFR2, VEGFR3, PDGFR, FGFR, c-Kit, and c-Fms, with IC50s 10nM, 30nM, 47nM, 84nM, 74nM, 140nM, and 146nM respectively [1-3]. |
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Pazopanib Hydrochloride |
|||
| A8347-S | ApexBio | Evaluation Sample | EUR 97.2 |
|
Description: Pazopanib HCl is a receptor tyrosine kinase inhibitor that targets multiple kinases, including VEGFR1, VEGFR2, VEGFR3, PDGFR, FGFR, c-Kit, and c-Fms, with IC50s 10nM, 30nM, 47nM, 84nM, 74nM, 140nM, and 146nM respectively [1-3]. |
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Bestatin hydrochloride |
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| A8621-10 | ApexBio | 10 mg | EUR 157.2 |
|
Description: Bestatin hydrochloride, also known as Ubenimex, is an inhibitor of aminopeptidase B and N (APN)/CD13 [1].Bestatin, an antibiotic of microbial origin, is a potent inhibitor of some aminopeptidases which can be administered to cultured cells, intact animals and humans with low toxicity. |
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Bestatin hydrochloride |
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| A8621-100 | ApexBio | 100 mg | EUR 532.8 |
|
Description: Bestatin hydrochloride, also known as Ubenimex, is an inhibitor of aminopeptidase B and N (APN)/CD13 [1].Bestatin, an antibiotic of microbial origin, is a potent inhibitor of some aminopeptidases which can be administered to cultured cells, intact animals and humans with low toxicity. |
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Bestatin hydrochloride |
|||
| A8621-25 | ApexBio | 25 mg | EUR 226.8 |
|
Description: Bestatin hydrochloride, also known as Ubenimex, is an inhibitor of aminopeptidase B and N (APN)/CD13 [1].Bestatin, an antibiotic of microbial origin, is a potent inhibitor of some aminopeptidases which can be administered to cultured cells, intact animals and humans with low toxicity. |
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Bestatin hydrochloride |
|||
| A8621-5 | ApexBio | 5 mg | EUR 129.6 |
|
Description: Bestatin hydrochloride, also known as Ubenimex, is an inhibitor of aminopeptidase B and N (APN)/CD13 [1].Bestatin, an antibiotic of microbial origin, is a potent inhibitor of some aminopeptidases which can be administered to cultured cells, intact animals and humans with low toxicity. |
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Flavopiridol hydrochloride |
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| A8640-10 | ApexBio | 10 mg | EUR 129.6 |
|
Description: Flavopiridol hydrochloride is a selective inhibitor of CDK1, CDK2, CDK4 and CDK6 with IC50 value all ~41 nM as well as CDK7 with 300nM [1] [2] [3].CDKs are protein kinase families which involve in the process of regulating transcription, mRNA processing, cell differentiation and cell cycle. |
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Flavopiridol hydrochloride |
|||
| A8640-100 | ApexBio | 100 mg | EUR 528 |
|
Description: Flavopiridol hydrochloride is a selective inhibitor of CDK1, CDK2, CDK4 and CDK6 with IC50 value all ~41 nM as well as CDK7 with 300nM [1] [2] [3].CDKs are protein kinase families which involve in the process of regulating transcription, mRNA processing, cell differentiation and cell cycle. |
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Flavopiridol hydrochloride |
|||
| A8640-1000 | ApexBio | 1 g | EUR 3259.2 |
|
Description: Flavopiridol hydrochloride is a selective inhibitor of CDK1, CDK2, CDK4 and CDK6 with IC50 value all ~41 nM as well as CDK7 with 300nM [1] [2] [3].CDKs are protein kinase families which involve in the process of regulating transcription, mRNA processing, cell differentiation and cell cycle. |
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Flavopiridol hydrochloride |
|||
| A8640-25 | ApexBio | 25 mg | EUR 199.2 |
|
Description: Flavopiridol hydrochloride is a selective inhibitor of CDK1, CDK2, CDK4 and CDK6 with IC50 value all ~41 nM as well as CDK7 with 300nM [1] [2] [3].CDKs are protein kinase families which involve in the process of regulating transcription, mRNA processing, cell differentiation and cell cycle. |
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Flavopiridol hydrochloride |
|||
| A8640-5.1 | ApexBio | 10 mM (in 1mL DMSO) | EUR 129.6 |
|
Description: Flavopiridol hydrochloride is a selective inhibitor of CDK1, CDK2, CDK4 and CDK6 with IC50 value all ~41 nM as well as CDK7 with 300nM [1] [2] [3].CDKs are protein kinase families which involve in the process of regulating transcription, mRNA processing, cell differentiation and cell cycle. |
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Regorafenib hydrochloride |
|||
| A3750-10 | ApexBio | 10 mg | EUR 150 |
|
Description: Regorafenib (BAY 73-4506) is a multikinase inhibitor with IC50 of 17, 40 and 69 nM c-KIT, VEGFR2, B-Raf. |
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Regorafenib hydrochloride |
|||
| A3750-100 | ApexBio | 100 mg | EUR 282 |
|
Description: Regorafenib (BAY 73-4506) is a multikinase inhibitor with IC50 of 17, 40 and 69 nM c-KIT, VEGFR2, B-Raf. |
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Regorafenib hydrochloride |
|||
| A3750-200 | ApexBio | 200 mg | EUR 582 |
|
Description: Regorafenib (BAY 73-4506) is a multikinase inhibitor with IC50 of 17, 40 and 69 nM c-KIT, VEGFR2, B-Raf. |
|||
Regorafenib hydrochloride |
|||
| A3750-5.1 | ApexBio | 10 mM (in 1mL DMSO) | EUR 199.2 |
|
Description: Regorafenib (BAY 73-4506) is a multikinase inhibitor with IC50 of 17, 40 and 69 nM c-KIT, VEGFR2, B-Raf. |
|||
Regorafenib hydrochloride |
|||
| A3750-50 | ApexBio | 50 mg | EUR 199.2 |
|
Description: Regorafenib (BAY 73-4506) is a multikinase inhibitor with IC50 of 17, 40 and 69 nM c-KIT, VEGFR2, B-Raf. |
|||
Resminostat hydrochloride |
|||
| A3755-10 | ApexBio | 10 mg | EUR 428.4 |
|
Description: Resminostat is an inhibitor of histone deacetylase (HDAC) with IC50 values of 42.5nM, 50.1nM and 71.8nM, respectively against HDAC1, 3 and 6 [1]. |
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Resminostat hydrochloride |
|||
| A3755-100 | ApexBio | 100 mg | EUR 1905.6 |
|
Description: Resminostat is an inhibitor of histone deacetylase (HDAC) with IC50 values of 42.5nM, 50.1nM and 71.8nM, respectively against HDAC1, 3 and 6 [1]. |
|||
Resminostat hydrochloride |
|||
| A3755-5.1 | ApexBio | 10 mM (in 1mL DMSO) | EUR 464.4 |
|
Description: Resminostat is an inhibitor of histone deacetylase (HDAC) with IC50 values of 42.5nM, 50.1nM and 71.8nM, respectively against HDAC1, 3 and 6 [1]. |
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Resminostat hydrochloride |
|||
| A3755-50 | ApexBio | 50 mg | EUR 1209.6 |
|
Description: Resminostat is an inhibitor of histone deacetylase (HDAC) with IC50 values of 42.5nM, 50.1nM and 71.8nM, respectively against HDAC1, 3 and 6 [1]. |
|||
Rimonabant hydrochloride |
|||
| A3766-10 | ApexBio | 10 mg | EUR 186 |
|
Description: Rimonabant, also known as SR141716, was the first selective central cannabinoid (CB1) receptor inverse agonist (Ki = 1.8 nM) to be developed as an appetite suppressant, anti-obesity drug. |
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Rimonabant hydrochloride |
|||
| A3766-100 | ApexBio | 100 mg | EUR 710.4 |
|
Description: Rimonabant, also known as SR141716, was the first selective central cannabinoid (CB1) receptor inverse agonist (Ki = 1.8 nM) to be developed as an appetite suppressant, anti-obesity drug. |
|||
Rimonabant hydrochloride |
|||
| A3766-5.1 | ApexBio | 10 mM (in 1mL DMSO) | EUR 199.2 |
|
Description: Rimonabant, also known as SR141716, was the first selective central cannabinoid (CB1) receptor inverse agonist (Ki = 1.8 nM) to be developed as an appetite suppressant, anti-obesity drug. |
|||
Rimonabant hydrochloride |
|||
| A3766-50 | ApexBio | 50 mg | EUR 494.4 |
|
Description: Rimonabant, also known as SR141716, was the first selective central cannabinoid (CB1) receptor inverse agonist (Ki = 1.8 nM) to be developed as an appetite suppressant, anti-obesity drug. |
|||
Rotigotine hydrochloride |
|||
| A3777-100 | ApexBio | 100 mg | EUR 480 |
|
Description: Rotigotine is dopamine D2 and D3 receptor agonist. Ki values are 13 and 0.71 nM for D2 and D3 respectively. Rotigotine also has significant affinity for 5-HT1A and adrenergic ?2B receptors. Rotigotine exhibits antiparkinsonian acitivity. |
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Rotigotine hydrochloride |
|||
| A3777-200 | ApexBio | 200 mg | EUR 812.4 |
|
Description: Rotigotine is dopamine D2 and D3 receptor agonist. Ki values are 13 and 0.71 nM for D2 and D3 respectively. Rotigotine also has significant affinity for 5-HT1A and adrenergic ?2B receptors. Rotigotine exhibits antiparkinsonian acitivity. |
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Rotigotine hydrochloride |
|||
| A3777-5.1 | ApexBio | 10 mM (in 1mL DMSO) | EUR 417.6 |
|
Description: Rotigotine is dopamine D2 and D3 receptor agonist. Ki values are 13 and 0.71 nM for D2 and D3 respectively. Rotigotine also has significant affinity for 5-HT1A and adrenergic ?2B receptors. Rotigotine exhibits antiparkinsonian acitivity. |
|||
Rotigotine hydrochloride |
|||
| A3777-50 | ApexBio | 50 mg | EUR 360 |
|
Description: Rotigotine is dopamine D2 and D3 receptor agonist. Ki values are 13 and 0.71 nM for D2 and D3 respectively. Rotigotine also has significant affinity for 5-HT1A and adrenergic ?2B receptors. Rotigotine exhibits antiparkinsonian acitivity. |
|||
Rotigotine hydrochloride |
|||
| A3777-500 | ApexBio | 500 mg | EUR 1663.2 |
|
Description: Rotigotine is dopamine D2 and D3 receptor agonist. Ki values are 13 and 0.71 nM for D2 and D3 respectively. Rotigotine also has significant affinity for 5-HT1A and adrenergic ?2B receptors. Rotigotine exhibits antiparkinsonian acitivity. |
|||
Tipiracil hydrochloride |
|||
| A3875-10 | ApexBio | 10 mg | EUR 553.2 |
|
Description: Tipiracil is an inhibitor of Thymidine phosphorylase (TP). Thymidine phosphorylase (TP)is a key enzyme in the pyrimidine nucleoside salvage pathway. |
|||
Tipiracil hydrochloride |
|||
| A3875-25 | ApexBio | 25 mg | EUR 774 |
|
Description: Tipiracil is an inhibitor of Thymidine phosphorylase (TP). Thymidine phosphorylase (TP)is a key enzyme in the pyrimidine nucleoside salvage pathway. |
|||
Tipiracil hydrochloride |
|||
| A3875-5 | ApexBio | 5 mg | EUR 382.8 |
|
Description: Tipiracil is an inhibitor of Thymidine phosphorylase (TP). Thymidine phosphorylase (TP)is a key enzyme in the pyrimidine nucleoside salvage pathway. |
|||
Tipiracil hydrochloride |
|||
| A3875-5.1 | ApexBio | 10 mM (in 1mL DMSO) | EUR 351.6 |
|
Description: Tipiracil is an inhibitor of Thymidine phosphorylase (TP). Thymidine phosphorylase (TP)is a key enzyme in the pyrimidine nucleoside salvage pathway. |
|||
Tipiracil hydrochloride |
|||
| A3875-50 | ApexBio | 50 mg | EUR 1230 |
|
Description: Tipiracil is an inhibitor of Thymidine phosphorylase (TP). Thymidine phosphorylase (TP)is a key enzyme in the pyrimidine nucleoside salvage pathway. |
|||
Vandetanib hydrochloride |
|||
| A3906-100 | ApexBio | 100 mg | EUR 517.2 |
|
Description: Description: IC50 Value: 40 nM (VEGFR2) [1]; 500 nM (EGFR) [2] Vandetanib is an anti-cancer drug that is used for the treatment of certain tumours of thethyroid gland. |
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Vandetanib hydrochloride |
|||
| A3906-25 | ApexBio | 25 mg | EUR 201.6 |
|
Description: Description: IC50 Value: 40 nM (VEGFR2) [1]; 500 nM (EGFR) [2] Vandetanib is an anti-cancer drug that is used for the treatment of certain tumours of thethyroid gland. |
|||
Vernakalant Hydrochloride |
|||
| A3915-10 | ApexBio | 10 mg | EUR 847.2 |
|
Description: IC50: Vernakalant inhibits two specific potassium currents, IKur (IC50 = 9 ??) and IKACh (IC50=10 ?M) which are only present in atrial myocardium [1].Vernakalant blocks atrial potassium channels, thereby prolonging repolarization. |
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Vernakalant Hydrochloride |
|||
| A3915-100 | ApexBio | 100 mg | EUR 3316.8 |
|
Description: IC50: Vernakalant inhibits two specific potassium currents, IKur (IC50 = 9 ??) and IKACh (IC50=10 ?M) which are only present in atrial myocardium [1].Vernakalant blocks atrial potassium channels, thereby prolonging repolarization. |
|||
Vernakalant Hydrochloride |
|||
| A3915-50 | ApexBio | 50 mg | EUR 2090.4 |
|
Description: IC50: Vernakalant inhibits two specific potassium currents, IKur (IC50 = 9 ??) and IKACh (IC50=10 ?M) which are only present in atrial myocardium [1].Vernakalant blocks atrial potassium channels, thereby prolonging repolarization. |
|||
Vilazodone Hydrochloride |
|||
| A3919-10 | ApexBio | 10 mg | EUR 129.6 |
|
Description: Vilazodone (EMD 68843; SB 659746A; 5-{4-[4-(5-cyano-3-indolyl)-butyl]-1-piperazinyl}-benzofuran-2-carboxamide hydrochloride) is a combined serotonin specific reuptake inhibitor (SSRI) and 5-HT1A receptor partial agonist currently under clinical evaluation for the treatment of major depression. |
|||
Vilazodone Hydrochloride |
|||
| A3919-5.1 | ApexBio | 10 mM (in 1mL DMSO) | EUR 129.6 |
|
Description: Vilazodone (EMD 68843; SB 659746A; 5-{4-[4-(5-cyano-3-indolyl)-butyl]-1-piperazinyl}-benzofuran-2-carboxamide hydrochloride) is a combined serotonin specific reuptake inhibitor (SSRI) and 5-HT1A receptor partial agonist currently under clinical evaluation for the treatment of major depression. |
|||
Vilazodone Hydrochloride |
|||
| A3919-50 | ApexBio | 50 mg | EUR 157.2 |
|
Description: Vilazodone (EMD 68843; SB 659746A; 5-{4-[4-(5-cyano-3-indolyl)-butyl]-1-piperazinyl}-benzofuran-2-carboxamide hydrochloride) is a combined serotonin specific reuptake inhibitor (SSRI) and 5-HT1A receptor partial agonist currently under clinical evaluation for the treatment of major depression. |
|||
Voreloxin Hydrochloride |
|||
| A3925-10 | ApexBio | 10 mg | EUR 895.2 |
|
Description: Voreloxin is a small molecule and a naphthyridine analogue with antineoplastic activity. Vosaroxin intercalates into DNA in a site-specific manner and blocks the re-ligation process carried out by topoisomerase II during DNA replication. |
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Voreloxin Hydrochloride |
|||
| A3925-5 | ApexBio | 5 mg | EUR 656.4 |
|
Description: Voreloxin is a small molecule and a naphthyridine analogue with antineoplastic activity. Vosaroxin intercalates into DNA in a site-specific manner and blocks the re-ligation process carried out by topoisomerase II during DNA replication. |
|||
Voreloxin Hydrochloride |
|||
| A3925-5.1 | ApexBio | 10 mM (in 1mL DMSO) | EUR 717.6 |
|
Description: Voreloxin is a small molecule and a naphthyridine analogue with antineoplastic activity. Vosaroxin intercalates into DNA in a site-specific manner and blocks the re-ligation process carried out by topoisomerase II during DNA replication. |
|||
PJ34 hydrochloride |
|||
| A4159-10 | ApexBio | 10 mg | EUR 142.8 |
|
Description: PJ34 is a novel and potent inhibitor of poly(ADP-ribose) polymerase (PARP), an enzyme involved in DNA repair and cell proliferation, that dose-dependently inhibits purified PARP enzyme in a cell-free assay with half maximal effective concentration EC50 value of 20 nM. |
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PJ34 hydrochloride |
|||
| A4159-5 | ApexBio | 5 mg | EUR 129.6 |
|
Description: PJ34 is a novel and potent inhibitor of poly(ADP-ribose) polymerase (PARP), an enzyme involved in DNA repair and cell proliferation, that dose-dependently inhibits purified PARP enzyme in a cell-free assay with half maximal effective concentration EC50 value of 20 nM. |
|||
PJ34 hydrochloride |
|||
| A4159-5.1 | ApexBio | 10 mM (in 1mL DMSO) | EUR 150 |
|
Description: PJ34 is a novel and potent inhibitor of poly(ADP-ribose) polymerase (PARP), an enzyme involved in DNA repair and cell proliferation, that dose-dependently inhibits purified PARP enzyme in a cell-free assay with half maximal effective concentration EC50 value of 20 nM. |
|||
PJ34 hydrochloride |
|||
| A4159-50 | ApexBio | 50 mg | EUR 296.4 |
|
Description: PJ34 is a novel and potent inhibitor of poly(ADP-ribose) polymerase (PARP), an enzyme involved in DNA repair and cell proliferation, that dose-dependently inhibits purified PARP enzyme in a cell-free assay with half maximal effective concentration EC50 value of 20 nM. |
|||
PJ34 hydrochloride |
|||
| A4159-S | ApexBio | Evaluation Sample | EUR 97.2 |
|
Description: PJ34 is a novel and potent inhibitor of poly(ADP-ribose) polymerase (PARP), an enzyme involved in DNA repair and cell proliferation, that dose-dependently inhibits purified PARP enzyme in a cell-free assay with half maximal effective concentration EC50 value of 20 nM. |
|||
Dimethylamine hydrochloride |
|||
| DB0410 | Bio Basic | 500g | EUR 116.38 |
Daunorubicin hydrochloride |
|||
| D001-10MG | TOKU-E | 10 mg | EUR 142.8 |
Daunorubicin hydrochloride |
|||
| D001-50MG | TOKU-E | 50 mg | EUR 480 |
Difloxacin hydrochloride |
|||
| D021-1G | TOKU-E | 1 g | EUR 133.2 |
Difloxacin hydrochloride |
|||
| D021-5G | TOKU-E | 5 g | EUR 438 |
Demeclocycline hydrochloride |
|||
| D032-1G | TOKU-E | 1 g | EUR 208.8 |
Demeclocycline hydrochloride |
|||
| D032-250MG | TOKU-E | 250 mg | EUR 105.6 |
Demeclocycline hydrochloride |
|||
| D032-5G | TOKU-E | 5 g | EUR 646.8 |
Doxycycline Hydrochloride |
|||
| D065-25MG | TOKU-E | 25mg | EUR 410.4 |
Doxycycline Hydrochloride |
|||
| D065-5MG | TOKU-E | 5mg | EUR 142.8 |
Dalbavancin Hydrochloride |
|||
| D092-10MG | TOKU-E | 10mg | EUR 152.4 |
Dalbavancin Hydrochloride |
|||
| D092-50MG | TOKU-E | 50mg | EUR 456 |
Cefepime Hydrochloride |
|||
| C009-100MG | TOKU-E | 100 mg | EUR 320.4 |
Ceftazidime Hydrochloride |
|||
| C020-1G | TOKU-E | 1 g | EUR 746.4 |
Niguldipine (hydrochloride) |
|||
| C3067-10 | ApexBio | 10 mg | EUR 164.4 |
|
Description: Ki = 0.16 nM: ?1A-adrenoceptor antagonistIC50s = 0.4 ?M: inhibits L-type Ca2+ channelsIC50s = 0.9 ?M: suppresses T-type Ca2+ channelsNiguldipine is a less potent Ca2+ channel blocker and potent, selective ?1A-adrenoceptor receptor antagonist. |
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Niguldipine (hydrochloride) |
|||
| C3067-25 | ApexBio | 25 mg | EUR 308.4 |
|
Description: Ki = 0.16 nM: ?1A-adrenoceptor antagonistIC50s = 0.4 ?M: inhibits L-type Ca2+ channelsIC50s = 0.9 ?M: suppresses T-type Ca2+ channelsNiguldipine is a less potent Ca2+ channel blocker and potent, selective ?1A-adrenoceptor receptor antagonist. |
|||
AD57 (hydrochloride) |
|||
| C3080-1 | ApexBio | 1 mg | EUR 141.6 |
|
Description: IC50: 2 nM: blocks the receptor tyrosine kinase RET in Drosophila.AD57, as a polypharmacological cancer therapeutic, is designed to regulate multiple targets related to cancer. |
|||
AD57 (hydrochloride) |
|||
| C3080-10 | ApexBio | 10 mg | EUR 714 |
|
Description: IC50: 2 nM: blocks the receptor tyrosine kinase RET in Drosophila.AD57, as a polypharmacological cancer therapeutic, is designed to regulate multiple targets related to cancer. |
|||
AD57 (hydrochloride) |
|||
| C3080-5 | ApexBio | 5 mg | EUR 428.4 |
|
Description: IC50: 2 nM: blocks the receptor tyrosine kinase RET in Drosophila.AD57, as a polypharmacological cancer therapeutic, is designed to regulate multiple targets related to cancer. |
|||
Pargyline (hydrochloride) |
|||
| C3106-1000 | ApexBio | 1 g | EUR 139.2 |
|
Description: IC50: 11.52 nM: inhibits monoamine oxidase (MAO) type A (MAO-A).IC50: 8.2 nM: blocks MAO type B (MAO-B).Pargyline, an irreversible and non-selective inhibitor of MAO, is used to treat moderate hypertension and cancer cells. |
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Pargyline (hydrochloride) |
|||
| C3106-5000 | ApexBio | 5 g | EUR 410.4 |
|
Description: IC50: 11.52 nM: inhibits monoamine oxidase (MAO) type A (MAO-A).IC50: 8.2 nM: blocks MAO type B (MAO-B).Pargyline, an irreversible and non-selective inhibitor of MAO, is used to treat moderate hypertension and cancer cells. |
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Clenbuterol (hydrochloride) |
|||
| C3119-100 | ApexBio | 100 mg | EUR 258 |
|
Description: Clenbuterol is a sympathomimetic ?2-adrenoceptor agonist. ?2-adrenoceptor agonists, mainly long-acting ?2-adrenoceptor agonists, are an important pharmacological approach to induce bronchodilation in patients with chronic obstructive pulmonary disease. |
|||
Clenbuterol (hydrochloride) |
|||
| C3119-25 | ApexBio | 25 mg | EUR 130.8 |
|
Description: Clenbuterol is a sympathomimetic ?2-adrenoceptor agonist. ?2-adrenoceptor agonists, mainly long-acting ?2-adrenoceptor agonists, are an important pharmacological approach to induce bronchodilation in patients with chronic obstructive pulmonary disease. |
|||
Clenbuterol (hydrochloride) |
|||
| C3119-5.1 | ApexBio | 10 mM (in 1mL DMSO) | EUR 135.6 |
|
Description: Clenbuterol is a sympathomimetic ?2-adrenoceptor agonist. ?2-adrenoceptor agonists, mainly long-acting ?2-adrenoceptor agonists, are an important pharmacological approach to induce bronchodilation in patients with chronic obstructive pulmonary disease. |
|||
Clenbuterol (hydrochloride) |
|||
| C3119-50 | ApexBio | 50 mg | EUR 189.6 |
|
Description: Clenbuterol is a sympathomimetic ?2-adrenoceptor agonist. ?2-adrenoceptor agonists, mainly long-acting ?2-adrenoceptor agonists, are an important pharmacological approach to induce bronchodilation in patients with chronic obstructive pulmonary disease. |
|||
CBL0137 (hydrochloride) |
|||
| C3192-10 | ApexBio | 10 mg | EUR 529.2 |
|
Description: EC50: 0.37 ?M for activating p53; 0.47 ?M for inhibiting NF-?B CBL0137 (hydrochloride) is a curaxin that activates p53 and inhibits NF-?B. |
|||
CBL0137 (hydrochloride) |
|||
| C3192-25 | ApexBio | 25 mg | EUR 1071.6 |
|
Description: EC50: 0.37 ?M for activating p53; 0.47 ?M for inhibiting NF-?B CBL0137 (hydrochloride) is a curaxin that activates p53 and inhibits NF-?B. |
|||
CBL0137 (hydrochloride) |
|||
| C3192-5 | ApexBio | 5 mg | EUR 331.2 |
|
Description: EC50: 0.37 ?M for activating p53; 0.47 ?M for inhibiting NF-?B CBL0137 (hydrochloride) is a curaxin that activates p53 and inhibits NF-?B. |
|||
CBL0137 (hydrochloride) |
|||
| C3192-5.1 | ApexBio | 10 mM (in 1mL DMSO) | EUR 282 |
|
Description: EC50: 0.37 ?M for activating p53; 0.47 ?M for inhibiting NF-?B CBL0137 (hydrochloride) is a curaxin that activates p53 and inhibits NF-?B. |
|||
CBL0137 (hydrochloride) |
|||
| C3192-50 | ApexBio | 50 mg | EUR 1851.6 |
|
Description: EC50: 0.37 ?M for activating p53; 0.47 ?M for inhibiting NF-?B CBL0137 (hydrochloride) is a curaxin that activates p53 and inhibits NF-?B. |
|||
CPTH2 (hydrochloride) |
|||
| C3208-10 | ApexBio | 10 mg | EUR 231.6 |
|
Description: CPTH2 is an inhibitor of HAT activity of Gcn5. |
|||
CPTH2 (hydrochloride) |
|||
| C3208-5 | ApexBio | 5 mg | EUR 192 |
|
Description: CPTH2 is an inhibitor of HAT activity of Gcn5. |
|||
Clinafloxacin (hydrochloride) |
|||
| C3345-100 | ApexBio | 100 mg | EUR 184.8 |
|
Description: Clinafloxacin is a broad-spectrum antibiotic of the quinolone carboxylic acid category that inhibits both DNA gyrase and topoisomerase IV dually in Streptococcus pneumonia. Clinafloxacin, a fluoroquinolone, is currently in development for oral and intravenous therapy of serious infections. |
|||
Clinafloxacin (hydrochloride) |
|||
| C3345-1000 | ApexBio | 1 g | EUR 686.4 |
|
Description: Clinafloxacin is a broad-spectrum antibiotic of the quinolone carboxylic acid category that inhibits both DNA gyrase and topoisomerase IV dually in Streptococcus pneumonia. Clinafloxacin, a fluoroquinolone, is currently in development for oral and intravenous therapy of serious infections. |
|||
Clinafloxacin (hydrochloride) |
|||
| C3345-250 | ApexBio | 250 mg | EUR 309.6 |
|
Description: Clinafloxacin is a broad-spectrum antibiotic of the quinolone carboxylic acid category that inhibits both DNA gyrase and topoisomerase IV dually in Streptococcus pneumonia. Clinafloxacin, a fluoroquinolone, is currently in development for oral and intravenous therapy of serious infections. |
|||
Clinafloxacin (hydrochloride) |
|||
| C3345-500 | ApexBio | 500 mg | EUR 459.6 |
|
Description: Clinafloxacin is a broad-spectrum antibiotic of the quinolone carboxylic acid category that inhibits both DNA gyrase and topoisomerase IV dually in Streptococcus pneumonia. Clinafloxacin, a fluoroquinolone, is currently in development for oral and intravenous therapy of serious infections. |
|||
Isoxsuprine (hydrochloride) |
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| C3347-10000 | ApexBio | 10 g | EUR 145.2 |
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Description: Isoxsuprine is a modulator of ?2 adrenoreceptor and has agonist or antagonist effects.The ?2 adrenoceptors are a class of G protein-coupled receptors that are targets for epinephrine. |
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Isoxsuprine (hydrochloride) |
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| C3347-5.1 | ApexBio | 10 mM (in 1mL DMSO) | EUR 135.6 |
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Description: Isoxsuprine is a modulator of ?2 adrenoreceptor and has agonist or antagonist effects.The ?2 adrenoceptors are a class of G protein-coupled receptors that are targets for epinephrine. |
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DAPI (hydrochloride) |
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| C3362-10 | ApexBio | 10 mg | EUR 146.4 |
DAPI (hydrochloride) |
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| C3362-25 | ApexBio | 25 mg | EUR 240 |
DAPI (hydrochloride) |
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| C3362-5 | ApexBio | 5 mg | EUR 111.6 |