So as to make clear mechanisms that result in CLL development, we investigated longitudinal adjustments in each the genetic and immunological eventualities.
Strategies: We carried out genetic and immunological longitudinal evaluation utilizing paired main samples from untreated CLL sufferers that underwent scientific development (sampling at analysis and development) and from sufferers with steady illness (sampling at analysis and at long-term asymptomatic follow-up).
Our evaluation of the immune kinetics discovered an more and more dysfunctional CD8+ T cell compartment in progressing sufferers that was not noticed in these sufferers that remained asymptomatic.
Particularly, terminally exhausted effector CD8+ T cells (T-betdim/-EomeshelloPD1hello) accrued, whereas the the co-expression of inhibitory receptors (PD1, CD244 and CD160) elevated, together with an altered gene expression profile in T cells solely in these sufferers that progressed. As well as, malignant cells from sufferers at scientific development confirmed enhanced capability to induce exhaustion-related markers in CD8+ T cells ex vivo primarily by way of a mechanism depending on soluble components together with IL-10.

Platelet Derived Growth Factor Receptor Alpha (PDGFRa) Polyclonal Antibody (Human), APC-Cy7 |
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4-CAC060Hu01-APC-Cy7 | Cloud-Clone |
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Description: A Rabbit polyclonal antibody against Human Platelet Derived Growth Factor Receptor Alpha (PDGFRa). This antibody is labeled with APC-Cy7. |
Platelet Derived Growth Factor Receptor Alpha (PDGFRa) Polyclonal Antibody (Human), Biotinylated |
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4-CAC060Hu01-Biotin | Cloud-Clone |
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Description: A Rabbit polyclonal antibody against Human Platelet Derived Growth Factor Receptor Alpha (PDGFRa). This antibody is labeled with Biotin. |
Platelet Derived Growth Factor Receptor Alpha (PDGFRa) Polyclonal Antibody (Human), Cy3 |
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4-CAC060Hu01-Cy3 | Cloud-Clone |
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Description: A Rabbit polyclonal antibody against Human Platelet Derived Growth Factor Receptor Alpha (PDGFRa). This antibody is labeled with Cy3. |
Platelet Derived Growth Factor Receptor Alpha (PDGFRa) Polyclonal Antibody (Human), FITC |
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4-CAC060Hu01-FITC | Cloud-Clone |
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Description: A Rabbit polyclonal antibody against Human Platelet Derived Growth Factor Receptor Alpha (PDGFRa). This antibody is labeled with FITC. |
Platelet Derived Growth Factor Receptor Alpha (PDGFRa) Polyclonal Antibody (Human), HRP |
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4-CAC060Hu01-HRP | Cloud-Clone |
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Description: A Rabbit polyclonal antibody against Human Platelet Derived Growth Factor Receptor Alpha (PDGFRa). This antibody is labeled with HRP. |
Platelet Derived Growth Factor Receptor Alpha (PDGFRa) Polyclonal Antibody (Human), PE |
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4-CAC060Hu01-PE | Cloud-Clone |
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Description: A Rabbit polyclonal antibody against Human Platelet Derived Growth Factor Receptor Alpha (PDGFRa). This antibody is labeled with PE. |
Platelet Derived Growth Factor Receptor Alpha (PDGFRa) Monoclonal Antibody (Human) |
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4-CAC060Hu22 | Cloud-Clone |
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Description: A Mouse monoclonal antibody against Human Platelet Derived Growth Factor Receptor Alpha (PDGFRa) |
Platelet Derived Growth Factor Receptor Alpha (PDGFRa) Monoclonal Antibody (Human), APC |
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4-CAC060Hu22-APC | Cloud-Clone |
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Description: A Mouse monoclonal antibody against Human Platelet Derived Growth Factor Receptor Alpha (PDGFRa). This antibody is labeled with APC. |
Platelet Derived Growth Factor Receptor Alpha (PDGFRa) Monoclonal Antibody (Human), APC-Cy7 |
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4-CAC060Hu22-APC-Cy7 | Cloud-Clone |
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Description: A Mouse monoclonal antibody against Human Platelet Derived Growth Factor Receptor Alpha (PDGFRa). This antibody is labeled with APC-Cy7. |
Platelet Derived Growth Factor Receptor Alpha (PDGFRa) Monoclonal Antibody (Human), Biotinylated |
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4-CAC060Hu22-Biotin | Cloud-Clone |
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Description: A Mouse monoclonal antibody against Human Platelet Derived Growth Factor Receptor Alpha (PDGFRa). This antibody is labeled with Biotin. |
Platelet Derived Growth Factor Receptor Alpha (PDGFRa) Monoclonal Antibody (Human), Cy3 |
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4-CAC060Hu22-Cy3 | Cloud-Clone |
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Description: A Mouse monoclonal antibody against Human Platelet Derived Growth Factor Receptor Alpha (PDGFRa). This antibody is labeled with Cy3. |
Platelet Derived Growth Factor Receptor Alpha (PDGFRa) Monoclonal Antibody (Human), FITC |
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4-CAC060Hu22-FITC | Cloud-Clone |
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Description: A Mouse monoclonal antibody against Human Platelet Derived Growth Factor Receptor Alpha (PDGFRa). This antibody is labeled with FITC. |
Platelet Derived Growth Factor Receptor Alpha (PDGFRa) Monoclonal Antibody (Human), HRP |
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4-CAC060Hu22-HRP | Cloud-Clone |
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Description: A Mouse monoclonal antibody against Human Platelet Derived Growth Factor Receptor Alpha (PDGFRa). This antibody is labeled with HRP. |
Platelet Derived Growth Factor Receptor Alpha (PDGFRa) Monoclonal Antibody (Human), PE |
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4-CAC060Hu22-PE | Cloud-Clone |
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Description: A Mouse monoclonal antibody against Human Platelet Derived Growth Factor Receptor Alpha (PDGFRa). This antibody is labeled with PE. |
Lamin B1 (LMNB1) Polyclonal Antibody (Human, Pig) |
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4-CAF548Hu01 | Cloud-Clone |
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Description: A Rabbit polyclonal antibody against Human, Pig Lamin B1 (LMNB1) |
Lamin B1 (LMNB1) Polyclonal Antibody (Human, Pig), APC |
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4-CAF548Hu01-APC | Cloud-Clone |
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Description: A Rabbit polyclonal antibody against Human, Pig Lamin B1 (LMNB1). This antibody is labeled with APC. |
Lamin B1 (LMNB1) Polyclonal Antibody (Human, Pig), APC-Cy7 |
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4-CAF548Hu01-APC-Cy7 | Cloud-Clone |
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Description: A Rabbit polyclonal antibody against Human, Pig Lamin B1 (LMNB1). This antibody is labeled with APC-Cy7. |
Lamin B1 (LMNB1) Polyclonal Antibody (Human, Pig), Biotinylated |
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4-CAF548Hu01-Biotin | Cloud-Clone |
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Description: A Rabbit polyclonal antibody against Human, Pig Lamin B1 (LMNB1). This antibody is labeled with Biotin. |
Lamin B1 (LMNB1) Polyclonal Antibody (Human, Pig), Cy3 |
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4-CAF548Hu01-Cy3 | Cloud-Clone |
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Description: A Rabbit polyclonal antibody against Human, Pig Lamin B1 (LMNB1). This antibody is labeled with Cy3. |
Lamin B1 (LMNB1) Polyclonal Antibody (Human, Pig), FITC |
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4-CAF548Hu01-FITC | Cloud-Clone |
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Description: A Rabbit polyclonal antibody against Human, Pig Lamin B1 (LMNB1). This antibody is labeled with FITC. |
Lamin B1 (LMNB1) Polyclonal Antibody (Human, Pig), HRP |
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4-CAF548Hu01-HRP | Cloud-Clone |
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Description: A Rabbit polyclonal antibody against Human, Pig Lamin B1 (LMNB1). This antibody is labeled with HRP. |
Lamin B1 (LMNB1) Polyclonal Antibody (Human, Pig), PE |
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4-CAF548Hu01-PE | Cloud-Clone |
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Description: A Rabbit polyclonal antibody against Human, Pig Lamin B1 (LMNB1). This antibody is labeled with PE. |
Lamin B1 (LMNB1) Monoclonal Antibody (Human) |
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4-CAF548Hu22 | Cloud-Clone |
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Description: A Mouse monoclonal antibody against Human Lamin B1 (LMNB1) |
Lamin B1 (LMNB1) Monoclonal Antibody (Human), APC |
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4-CAF548Hu22-APC | Cloud-Clone |
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Description: A Mouse monoclonal antibody against Human Lamin B1 (LMNB1). This antibody is labeled with APC. |
Lamin B1 (LMNB1) Monoclonal Antibody (Human), APC-Cy7 |
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4-CAF548Hu22-APC-Cy7 | Cloud-Clone |
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Description: A Mouse monoclonal antibody against Human Lamin B1 (LMNB1). This antibody is labeled with APC-Cy7. |
Lamin B1 (LMNB1) Monoclonal Antibody (Human), Biotinylated |
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4-CAF548Hu22-Biotin | Cloud-Clone |
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Description: A Mouse monoclonal antibody against Human Lamin B1 (LMNB1). This antibody is labeled with Biotin. |
Lamin B1 (LMNB1) Monoclonal Antibody (Human), Cy3 |
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4-CAF548Hu22-Cy3 | Cloud-Clone |
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Description: A Mouse monoclonal antibody against Human Lamin B1 (LMNB1). This antibody is labeled with Cy3. |
Lamin B1 (LMNB1) Monoclonal Antibody (Human), FITC |
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4-CAF548Hu22-FITC | Cloud-Clone |
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Description: A Mouse monoclonal antibody against Human Lamin B1 (LMNB1). This antibody is labeled with FITC. |
Lamin B1 (LMNB1) Monoclonal Antibody (Human), HRP |
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4-CAF548Hu22-HRP | Cloud-Clone |
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Description: A Mouse monoclonal antibody against Human Lamin B1 (LMNB1). This antibody is labeled with HRP. |
Lamin B1 (LMNB1) Monoclonal Antibody (Human), PE |
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4-CAF548Hu22-PE | Cloud-Clone |
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Description: A Mouse monoclonal antibody against Human Lamin B1 (LMNB1). This antibody is labeled with PE. |
Lamin A/C (LMNA) Polyclonal Antibody (Human) |
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4-CAF550Hu01 | Cloud-Clone |
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Description: A Rabbit polyclonal antibody against Human Lamin A/C (LMNA) |
Lamin A/C (LMNA) Polyclonal Antibody (Human), APC |
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4-CAF550Hu01-APC | Cloud-Clone |
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Description: A Rabbit polyclonal antibody against Human Lamin A/C (LMNA). This antibody is labeled with APC. |
Lamin A/C (LMNA) Polyclonal Antibody (Human), APC-Cy7 |
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4-CAF550Hu01-APC-Cy7 | Cloud-Clone |
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Description: A Rabbit polyclonal antibody against Human Lamin A/C (LMNA). This antibody is labeled with APC-Cy7. |
Lamin A/C (LMNA) Polyclonal Antibody (Human), Biotinylated |
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4-CAF550Hu01-Biotin | Cloud-Clone |
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Description: A Rabbit polyclonal antibody against Human Lamin A/C (LMNA). This antibody is labeled with Biotin. |
Lamin A/C (LMNA) Polyclonal Antibody (Human), Cy3 |
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4-CAF550Hu01-Cy3 | Cloud-Clone |
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Description: A Rabbit polyclonal antibody against Human Lamin A/C (LMNA). This antibody is labeled with Cy3. |
Lamin A/C (LMNA) Polyclonal Antibody (Human), FITC |
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4-CAF550Hu01-FITC | Cloud-Clone |
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Description: A Rabbit polyclonal antibody against Human Lamin A/C (LMNA). This antibody is labeled with FITC. |
Lamin A/C (LMNA) Polyclonal Antibody (Human), HRP |
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4-CAF550Hu01-HRP | Cloud-Clone |
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Description: A Rabbit polyclonal antibody against Human Lamin A/C (LMNA). This antibody is labeled with HRP. |
Lamin A/C (LMNA) Polyclonal Antibody (Human), PE |
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4-CAF550Hu01-PE | Cloud-Clone |
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Description: A Rabbit polyclonal antibody against Human Lamin A/C (LMNA). This antibody is labeled with PE. |
Lamin A/C (LMNA) Monoclonal Antibody (Human) |
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4-CAF550Hu22 | Cloud-Clone |
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Description: A Mouse monoclonal antibody against Human Lamin A/C (LMNA) |
Lamin A/C (LMNA) Monoclonal Antibody (Human), APC |
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4-CAF550Hu22-APC | Cloud-Clone |
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Description: A Mouse monoclonal antibody against Human Lamin A/C (LMNA). This antibody is labeled with APC. |
Lamin A/C (LMNA) Monoclonal Antibody (Human), APC-Cy7 |
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4-CAF550Hu22-APC-Cy7 | Cloud-Clone |
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Description: A Mouse monoclonal antibody against Human Lamin A/C (LMNA). This antibody is labeled with APC-Cy7. |
Lamin A/C (LMNA) Monoclonal Antibody (Human), Biotinylated |
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4-CAF550Hu22-Biotin | Cloud-Clone |
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Description: A Mouse monoclonal antibody against Human Lamin A/C (LMNA). This antibody is labeled with Biotin. |
Lamin A/C (LMNA) Monoclonal Antibody (Human), Cy3 |
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4-CAF550Hu22-Cy3 | Cloud-Clone |
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Description: A Mouse monoclonal antibody against Human Lamin A/C (LMNA). This antibody is labeled with Cy3. |
Lamin A/C (LMNA) Monoclonal Antibody (Human), FITC |
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4-CAF550Hu22-FITC | Cloud-Clone |
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Description: A Mouse monoclonal antibody against Human Lamin A/C (LMNA). This antibody is labeled with FITC. |
Lamin A/C (LMNA) Monoclonal Antibody (Human), HRP |
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4-CAF550Hu22-HRP | Cloud-Clone |
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Description: A Mouse monoclonal antibody against Human Lamin A/C (LMNA). This antibody is labeled with HRP. |
Lamin A/C (LMNA) Monoclonal Antibody (Human), PE |
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4-CAF550Hu22-PE | Cloud-Clone |
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Description: A Mouse monoclonal antibody against Human Lamin A/C (LMNA). This antibody is labeled with PE. |
ATPase, Na+/K+ Transporting Alpha 1 Polypeptide (ATP1a1) Polyclonal Antibody (Human) |
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4-CAG369Hu01 | Cloud-Clone |
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Description: A Rabbit polyclonal antibody against Human ATPase, Na+/K+ Transporting Alpha 1 Polypeptide (ATP1a1) |
ATPase, Na+/K+ Transporting Alpha 1 Polypeptide (ATP1a1) Polyclonal Antibody (Human), APC |
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4-CAG369Hu01-APC | Cloud-Clone |
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Description: A Rabbit polyclonal antibody against Human ATPase, Na+/K+ Transporting Alpha 1 Polypeptide (ATP1a1). This antibody is labeled with APC. |
ATPase, Na+/K+ Transporting Alpha 1 Polypeptide (ATP1a1) Polyclonal Antibody (Human), APC-Cy7 |
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4-CAG369Hu01-APC-Cy7 | Cloud-Clone |
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Description: A Rabbit polyclonal antibody against Human ATPase, Na+/K+ Transporting Alpha 1 Polypeptide (ATP1a1). This antibody is labeled with APC-Cy7. |
ATPase, Na+/K+ Transporting Alpha 1 Polypeptide (ATP1a1) Polyclonal Antibody (Human), Biotinylated |
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4-CAG369Hu01-Biotin | Cloud-Clone |
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Description: A Rabbit polyclonal antibody against Human ATPase, Na+/K+ Transporting Alpha 1 Polypeptide (ATP1a1). This antibody is labeled with Biotin. |
ATPase, Na+/K+ Transporting Alpha 1 Polypeptide (ATP1a1) Polyclonal Antibody (Human), Cy3 |
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4-CAG369Hu01-Cy3 | Cloud-Clone |
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Description: A Rabbit polyclonal antibody against Human ATPase, Na+/K+ Transporting Alpha 1 Polypeptide (ATP1a1). This antibody is labeled with Cy3. |
ATPase, Na+/K+ Transporting Alpha 1 Polypeptide (ATP1a1) Polyclonal Antibody (Human), FITC |
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4-CAG369Hu01-FITC | Cloud-Clone |
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Description: A Rabbit polyclonal antibody against Human ATPase, Na+/K+ Transporting Alpha 1 Polypeptide (ATP1a1). This antibody is labeled with FITC. |
ATPase, Na+/K+ Transporting Alpha 1 Polypeptide (ATP1a1) Polyclonal Antibody (Human), HRP |
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4-CAG369Hu01-HRP | Cloud-Clone |
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Description: A Rabbit polyclonal antibody against Human ATPase, Na+/K+ Transporting Alpha 1 Polypeptide (ATP1a1). This antibody is labeled with HRP. |
ATPase, Na+/K+ Transporting Alpha 1 Polypeptide (ATP1a1) Polyclonal Antibody (Human), PE |
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4-CAG369Hu01-PE | Cloud-Clone |
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Description: A Rabbit polyclonal antibody against Human ATPase, Na+/K+ Transporting Alpha 1 Polypeptide (ATP1a1). This antibody is labeled with PE. |
ATPase, Na+/K+ Transporting Alpha 1 Polypeptide (ATP1a1) Monoclonal Antibody (Human) |
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4-CAG369Hu22 | Cloud-Clone |
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Description: A Mouse monoclonal antibody against Human ATPase, Na+/K+ Transporting Alpha 1 Polypeptide (ATP1a1) |
ATPase, Na+/K+ Transporting Alpha 1 Polypeptide (ATP1a1) Monoclonal Antibody (Human), APC |
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4-CAG369Hu22-APC | Cloud-Clone |
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Description: A Mouse monoclonal antibody against Human ATPase, Na+/K+ Transporting Alpha 1 Polypeptide (ATP1a1). This antibody is labeled with APC. |
ATPase, Na+/K+ Transporting Alpha 1 Polypeptide (ATP1a1) Monoclonal Antibody (Human), APC-Cy7 |
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4-CAG369Hu22-APC-Cy7 | Cloud-Clone |
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Description: A Mouse monoclonal antibody against Human ATPase, Na+/K+ Transporting Alpha 1 Polypeptide (ATP1a1). This antibody is labeled with APC-Cy7. |
ATPase, Na+/K+ Transporting Alpha 1 Polypeptide (ATP1a1) Monoclonal Antibody (Human), Biotinylated |
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4-CAG369Hu22-Biotin | Cloud-Clone |
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Description: A Mouse monoclonal antibody against Human ATPase, Na+/K+ Transporting Alpha 1 Polypeptide (ATP1a1). This antibody is labeled with Biotin. |
ATPase, Na+/K+ Transporting Alpha 1 Polypeptide (ATP1a1) Monoclonal Antibody (Human), Cy3 |
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4-CAG369Hu22-Cy3 | Cloud-Clone |
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Description: A Mouse monoclonal antibody against Human ATPase, Na+/K+ Transporting Alpha 1 Polypeptide (ATP1a1). This antibody is labeled with Cy3. |
ATPase, Na+/K+ Transporting Alpha 1 Polypeptide (ATP1a1) Monoclonal Antibody (Human), FITC |
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4-CAG369Hu22-FITC | Cloud-Clone |
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Description: A Mouse monoclonal antibody against Human ATPase, Na+/K+ Transporting Alpha 1 Polypeptide (ATP1a1). This antibody is labeled with FITC. |
ATPase, Na+/K+ Transporting Alpha 1 Polypeptide (ATP1a1) Monoclonal Antibody (Human), HRP |
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4-CAG369Hu22-HRP | Cloud-Clone |
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Description: A Mouse monoclonal antibody against Human ATPase, Na+/K+ Transporting Alpha 1 Polypeptide (ATP1a1). This antibody is labeled with HRP. |
ATPase, Na+/K+ Transporting Alpha 1 Polypeptide (ATP1a1) Monoclonal Antibody (Human), PE |
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4-CAG369Hu22-PE | Cloud-Clone |
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Description: A Mouse monoclonal antibody against Human ATPase, Na+/K+ Transporting Alpha 1 Polypeptide (ATP1a1). This antibody is labeled with PE. |
Voltage Dependent Anion Channel Protein 1 (VDAC1) Polyclonal Antibody (Human) |
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4-CAG901Hu01 | Cloud-Clone |
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Description: A Rabbit polyclonal antibody against Human Voltage Dependent Anion Channel Protein 1 (VDAC1) |
Voltage Dependent Anion Channel Protein 1 (VDAC1) Polyclonal Antibody (Human), APC |
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4-CAG901Hu01-APC | Cloud-Clone |
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Description: A Rabbit polyclonal antibody against Human Voltage Dependent Anion Channel Protein 1 (VDAC1). This antibody is labeled with APC. |
Voltage Dependent Anion Channel Protein 1 (VDAC1) Polyclonal Antibody (Human), APC-Cy7 |
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4-CAG901Hu01-APC-Cy7 | Cloud-Clone |
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Description: A Rabbit polyclonal antibody against Human Voltage Dependent Anion Channel Protein 1 (VDAC1). This antibody is labeled with APC-Cy7. |
Voltage Dependent Anion Channel Protein 1 (VDAC1) Polyclonal Antibody (Human), Biotinylated |
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4-CAG901Hu01-Biotin | Cloud-Clone |
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Description: A Rabbit polyclonal antibody against Human Voltage Dependent Anion Channel Protein 1 (VDAC1). This antibody is labeled with Biotin. |
Voltage Dependent Anion Channel Protein 1 (VDAC1) Polyclonal Antibody (Human), Cy3 |
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4-CAG901Hu01-Cy3 | Cloud-Clone |
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Description: A Rabbit polyclonal antibody against Human Voltage Dependent Anion Channel Protein 1 (VDAC1). This antibody is labeled with Cy3. |
Voltage Dependent Anion Channel Protein 1 (VDAC1) Polyclonal Antibody (Human), FITC |
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4-CAG901Hu01-FITC | Cloud-Clone |
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Description: A Rabbit polyclonal antibody against Human Voltage Dependent Anion Channel Protein 1 (VDAC1). This antibody is labeled with FITC. |
Voltage Dependent Anion Channel Protein 1 (VDAC1) Polyclonal Antibody (Human), HRP |
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4-CAG901Hu01-HRP | Cloud-Clone |
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Description: A Rabbit polyclonal antibody against Human Voltage Dependent Anion Channel Protein 1 (VDAC1). This antibody is labeled with HRP. |
Voltage Dependent Anion Channel Protein 1 (VDAC1) Polyclonal Antibody (Human), PE |
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4-CAG901Hu01-PE | Cloud-Clone |
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Description: A Rabbit polyclonal antibody against Human Voltage Dependent Anion Channel Protein 1 (VDAC1). This antibody is labeled with PE. |
Voltage Dependent Anion Channel Protein 1 (VDAC1) Monoclonal Antibody (Human) |
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4-CAG901Hu22 | Cloud-Clone |
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Description: A Mouse monoclonal antibody against Human Voltage Dependent Anion Channel Protein 1 (VDAC1) |
Voltage Dependent Anion Channel Protein 1 (VDAC1) Monoclonal Antibody (Human), APC |
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4-CAG901Hu22-APC | Cloud-Clone |
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Description: A Mouse monoclonal antibody against Human Voltage Dependent Anion Channel Protein 1 (VDAC1). This antibody is labeled with APC. |
Voltage Dependent Anion Channel Protein 1 (VDAC1) Monoclonal Antibody (Human), APC-Cy7 |
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4-CAG901Hu22-APC-Cy7 | Cloud-Clone |
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Description: A Mouse monoclonal antibody against Human Voltage Dependent Anion Channel Protein 1 (VDAC1). This antibody is labeled with APC-Cy7. |
Voltage Dependent Anion Channel Protein 1 (VDAC1) Monoclonal Antibody (Human), Biotinylated |
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4-CAG901Hu22-Biotin | Cloud-Clone |
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Description: A Mouse monoclonal antibody against Human Voltage Dependent Anion Channel Protein 1 (VDAC1). This antibody is labeled with Biotin. |
Voltage Dependent Anion Channel Protein 1 (VDAC1) Monoclonal Antibody (Human), Cy3 |
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4-CAG901Hu22-Cy3 | Cloud-Clone |
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Description: A Mouse monoclonal antibody against Human Voltage Dependent Anion Channel Protein 1 (VDAC1). This antibody is labeled with Cy3. |
Voltage Dependent Anion Channel Protein 1 (VDAC1) Monoclonal Antibody (Human), FITC |
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4-CAG901Hu22-FITC | Cloud-Clone |
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Description: A Mouse monoclonal antibody against Human Voltage Dependent Anion Channel Protein 1 (VDAC1). This antibody is labeled with FITC. |
Voltage Dependent Anion Channel Protein 1 (VDAC1) Monoclonal Antibody (Human), HRP |
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4-CAG901Hu22-HRP | Cloud-Clone |
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Description: A Mouse monoclonal antibody against Human Voltage Dependent Anion Channel Protein 1 (VDAC1). This antibody is labeled with HRP. |
Voltage Dependent Anion Channel Protein 1 (VDAC1) Monoclonal Antibody (Human), PE |
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4-CAG901Hu22-PE | Cloud-Clone |
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Description: A Mouse monoclonal antibody against Human Voltage Dependent Anion Channel Protein 1 (VDAC1). This antibody is labeled with PE. |
Human Angiotensin II (AngII) CLIA Kit |
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4-CCA005Hu | Cloud-Clone |
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Description: Competitive Inhibition chemiluminescent immunoassay for detection of Human Angiotensin II (AngII)Serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids |
Human Glycated Hemoglobin A1c (HbA1c) CLIA Kit |
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4-CCA190Hu | Cloud-Clone |
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Description: Competitive Inhibition chemiluminescent immunoassay for detection of Human Glycated Hemoglobin A1c (HbA1c)serum, plasma and erythrocyte lysates |
Human Anti-Mullerian Hormone (AMH) CLIA Kit |
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4-CCA228Hu | Cloud-Clone |
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Description: Competitive Inhibition chemiluminescent immunoassay for detection of Human Anti-Mullerian Hormone (AMH)Serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids. |
General Bovine Serum Albumin (BSA) CLIA Kit |
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4-CCA248Ge | Cloud-Clone |
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Description: Competitive Inhibition chemiluminescent immunoassay for detection of General Bovine Serum Albumin (BSA)Serum, plasma and other biological fluids |
Cattle Substance P (SP) CLIA Kit |
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4-CCA393Bo | Cloud-Clone |
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Description: Competitive Inhibition chemiluminescent immunoassay for detection of Cattle Substance P (SP)Serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids |
Dog Substance P (SP) CLIA Kit |
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4-CCA393Ca | Cloud-Clone |
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Description: Competitive Inhibition chemiluminescent immunoassay for detection of Dog Substance P (SP)Serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids |
Guinea pig Substance P (SP) CLIA Kit |
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4-CCA393Gu | Cloud-Clone |
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Description: Competitive Inhibition chemiluminescent immunoassay for detection of Guinea pig Substance P (SP)Serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids |
Human Substance P (SP) CLIA Kit |
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4-CCA393Hu | Cloud-Clone |
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Description: Competitive Inhibition chemiluminescent immunoassay for detection of Human Substance P (SP)Serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids. |
Mouse Substance P (SP) CLIA Kit |
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4-CCA393Mu | Cloud-Clone |
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|
Description: Competitive Inhibition chemiluminescent immunoassay for detection of Mouse Substance P (SP)Serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids |
Rat Substance P (SP) CLIA Kit |
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4-CCA393Ra | Cloud-Clone |
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|
Description: Competitive Inhibition chemiluminescent immunoassay for detection of Rat Substance P (SP)serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids |
General Dehydroepiandrosterone (DHEA) CLIA Kit |
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4-CCA398Ge | Cloud-Clone |
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|
Description: Competitive Inhibition chemiluminescent immunoassay for detection of General Dehydroepiandrosterone (DHEA)serum, plasma and other biological fluids |
ELISA Kit for Luteinizing Hormone (LH) |
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4-CCA441Mu | Cloud-Clone |
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Description: Enzyme-linked immunosorbent assay based on the Competitive Inhibition method for detection of Luteinizing Hormone (LH) in samples from Serum, plasma and other biological fluids with no significant corss-reactivity with analogues from other species. |
Rat Luteinizing Hormone (LH) CLIA Kit |
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4-CCA441Ra | Cloud-Clone |
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|
Description: Competitive Inhibition chemiluminescent immunoassay for detection of Rat Luteinizing Hormone (LH)serum, plasma and other biological fluids |
Human C-Peptide (CP) CLIA Kit |
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4-CCA447Hu | Cloud-Clone |
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|
Description: Competitive Inhibition chemiluminescent immunoassay for detection of Human C-Peptide (CP)Serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids |
Rat C-Peptide (CP) CLIA Kit |
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4-CCA447Ra | Cloud-Clone |
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|
Description: Competitive Inhibition chemiluminescent immunoassay for detection of Rat C-Peptide (CP)Serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids |
Human Insulin (INS) CLIA Kit |
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4-CCA448Hu | Cloud-Clone |
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Description: Competitive Inhibition chemiluminescent immunoassay for detection of Human Insulin (INS)Serum, plasma, cell culture supernates and other biological fluids |
Rat Insulin (INS) CLIA Kit |
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4-CCA448Ra | Cloud-Clone |
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Description: Competitive Inhibition chemiluminescent immunoassay for detection of Rat Insulin (INS)Serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids |
General Thyroxine (T4) CLIA Kit |
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4-CCA452Ge | Cloud-Clone |
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Description: Competitive Inhibition chemiluminescent immunoassay for detection of General Thyroxine (T4)Serum, plasma and other biological fluids |
General Triiodothyronine (T3) CLIA Kit |
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4-CCA453Ge | Cloud-Clone |
|
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Description: Competitive Inhibition chemiluminescent immunoassay for detection of General Triiodothyronine (T3)Serum, plasma and other biological fluids |
General Estriol (E3) CLIA Kit |
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4-CCA455Ge | Cloud-Clone |
|
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Description: Competitive Inhibition chemiluminescent immunoassay for detection of General Estriol (E3)Serum, plasma and other biological fluids |
General Testosterone (Testo) CLIA Kit |
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4-CCA458Ge | Cloud-Clone |
|
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Description: Competitive Inhibition chemiluminescent immunoassay for detection of General Testosterone (Testo)serum, plasma and other biological fluids |
General Progesterone (PG) CLIA Kit |
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4-CCA459Ge | Cloud-Clone |
|
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Description: Competitive Inhibition chemiluminescent immunoassay for detection of General Progesterone (PG)Serum, plasma and other biological fluids |
General Estradiol (E2) CLIA Kit |
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4-CCA461Ge | Cloud-Clone |
|
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Description: Competitive Inhibition chemiluminescent immunoassay for detection of General Estradiol (E2)Serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids |
General Cortisol (Cor) CLIA Kit |
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4-CCA462Ge | Cloud-Clone |
|
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Description: Competitive Inhibition chemiluminescent immunoassay for detection of General Cortisol (Cor)serum, plasma, urine and other biological fluids |
Human Endothelin 1 (EDN1) CLIA Kit |
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4-CCA482Hu | Cloud-Clone |
|
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Description: Competitive Inhibition chemiluminescent immunoassay for detection of Human Endothelin 1 (EDN1)Serum, plasma and other biological fluids |
Mouse D-Dimer (D2D) CLIA Kit |
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4-CCA506Mu | Cloud-Clone |
|
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Description: Competitive Inhibition chemiluminescent immunoassay for detection of Mouse D-Dimer (D2D)Plasma |
General Corticosterone (Cort) CLIA Kit |
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4-CCA540Ge | Cloud-Clone |
|
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Description: Competitive Inhibition chemiluminescent immunoassay for detection of General Corticosterone (Cort)serum, plasma, urine and other biological fluids |
Cattle Immunoglobulin G (IgG) CLIA Kit |
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4-CCA544Bo | Cloud-Clone |
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Description: Competitive Inhibition chemiluminescent immunoassay for detection of Cattle Immunoglobulin G (IgG)Serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids |
Dog Immunoglobulin G (IgG) CLIA Kit |
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4-CCA544Ca | Cloud-Clone |
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Description: Competitive Inhibition chemiluminescent immunoassay for detection of Dog Immunoglobulin G (IgG)Serum, plasma and other biological fluids |
Goat Immunoglobulin G (IgG) CLIA Kit |
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4-CCA544Cp | Cloud-Clone |
|
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Description: Competitive Inhibition chemiluminescent immunoassay for detection of Goat Immunoglobulin G (IgG)Serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids |
Horse Immunoglobulin G (IgG) CLIA Kit |
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4-CCA544Eq | Cloud-Clone |
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Description: Competitive Inhibition chemiluminescent immunoassay for detection of Horse Immunoglobulin G (IgG)Serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids |
Gallus Immunoglobulin G (IgG) CLIA Kit |
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4-CCA544Ga | Cloud-Clone |
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Description: Competitive Inhibition chemiluminescent immunoassay for detection of Gallus Immunoglobulin G (IgG)Serum, plasma and other biological fluids |
Guinea pig Immunoglobulin G (IgG) CLIA Kit |
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4-CCA544Gu | Cloud-Clone |
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Description: Competitive Inhibition chemiluminescent immunoassay for detection of Guinea pig Immunoglobulin G (IgG)Serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids |
Human Immunoglobulin G (IgG) CLIA Kit |
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4-CCA544Hu | Cloud-Clone |
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Description: Competitive Inhibition chemiluminescent immunoassay for detection of Human Immunoglobulin G (IgG)Serum, plasma and other biological fluids |
Mouse Immunoglobulin G (IgG) CLIA Kit |
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4-CCA544Mu | Cloud-Clone |
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Description: Competitive Inhibition chemiluminescent immunoassay for detection of Mouse Immunoglobulin G (IgG)Serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids |
Pig Immunoglobulin G (IgG) CLIA Kit |
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4-CCA544Po | Cloud-Clone |
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Description: Competitive Inhibition chemiluminescent immunoassay for detection of Pig Immunoglobulin G (IgG)Serum, plasma and other biological fluids |
Rat Immunoglobulin G (IgG) CLIA Kit |
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4-CCA544Ra | Cloud-Clone |
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Description: Competitive Inhibition chemiluminescent immunoassay for detection of Rat Immunoglobulin G (IgG)Serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids |
Rabbit Immunoglobulin G (IgG) CLIA Kit |
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4-CCA544Rb | Cloud-Clone |
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Description: Competitive Inhibition chemiluminescent immunoassay for detection of Rabbit Immunoglobulin G (IgG)Serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids |
Human Kallikrein 10 (KLK10) CLIA Kit |
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4-CCA697Hu | Cloud-Clone |
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Description: Competitive Inhibition chemiluminescent immunoassay for detection of Human Kallikrein 10 (KLK10)Serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids |
General Indole 3 Acetic Acid (IAA) CLIA Kit |
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4-CCA737Ge | Cloud-Clone |
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Description: Competitive Inhibition chemiluminescent immunoassay for detection of General Indole 3 Acetic Acid (IAA)Tissue or cell culture supernates |
Human Beta-Endorphin (bEP) CLIA Kit |
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4-CCA806Hu | Cloud-Clone |
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Description: Competitive Inhibition chemiluminescent immunoassay for detection of Human Beta-Endorphin (bEP)Serum, plasma, cerebrospinal fluid and other biological fluids |
Mouse Beta-Endorphin (bEP) CLIA Kit |
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4-CCA806Mu | Cloud-Clone |
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Description: Competitive Inhibition chemiluminescent immunoassay for detection of Mouse Beta-Endorphin (bEP)Serum, plasma, cerebrospinal fluid and other biological fluids |
Rat Beta-Endorphin (bEP) CLIA Kit |
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4-CCA806Ra | Cloud-Clone |
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Description: Competitive Inhibition chemiluminescent immunoassay for detection of Rat Beta-Endorphin (bEP)Serum, plasma, tissue homogenates, cell lysates, cerebrospinal fluid, cell culture supernates and other biological fluids |
Human Angiotensin I (AngI) CLIA Kit |
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4-CCA811Hu | Cloud-Clone |
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Description: Competitive Inhibition chemiluminescent immunoassay for detection of Human Angiotensin I (AngI)Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids |
ELISA Kit for Follicle Stimulating Hormone (FSH) |
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4-CCA830Mu | Cloud-Clone |
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Description: Enzyme-linked immunosorbent assay based on the Competitive Inhibition method for detection of Follicle Stimulating Hormone (FSH) in samples from Serum, plasma and other biological fluids with no significant corss-reactivity with analogues from other species. |
Rat Follicle Stimulating Hormone (FSH) CLIA Kit |
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4-CCA830Ra | Cloud-Clone |
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Description: Competitive Inhibition chemiluminescent immunoassay for detection of Rat Follicle Stimulating Hormone (FSH)Serum, plasma and other biological fluids |
Human Adrenocorticotropic Hormone (ACTH) CLIA Kit |
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4-CCA836Hu | Cloud-Clone |
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Description: Competitive Inhibition chemiluminescent immunoassay for detection of Human Adrenocorticotropic Hormone (ACTH)serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids |
Mouse Adrenocorticotropic Hormone (ACTH) CLIA Kit |
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4-CCA836Mu | Cloud-Clone |
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Description: Competitive Inhibition chemiluminescent immunoassay for detection of Mouse Adrenocorticotropic Hormone (ACTH)Serum, plasma and other biological fluids |
Rat Adrenocorticotropic Hormone (ACTH) CLIA Kit |
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4-CCA836Ra | Cloud-Clone |
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Description: Competitive Inhibition chemiluminescent immunoassay for detection of Rat Adrenocorticotropic Hormone (ACTH)serum, plasma and other biological fluids |
ELISA Kit for Gonadotropin Releasing Hormone (GnRH) |
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4-CCA843Mu | Cloud-Clone |
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Description: Enzyme-linked immunosorbent assay based on the Competitive Inhibition method for detection of Gonadotropin Releasing Hormone (GnRH) in samples from Serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids with no significant corss-reactivity with analogues from other species. |
General Dopamine (DA) CLIA Kit |
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4-CCA851Ge | Cloud-Clone |
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Description: Competitive Inhibition chemiluminescent immunoassay for detection of General Dopamine (DA)serum, plasma and other biological fluids |
Human Apelin 12 (AP12) CLIA Kit |
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4-CCA856Hu | Cloud-Clone |
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Description: Competitive Inhibition chemiluminescent immunoassay for detection of Human Apelin 12 (AP12)Serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids |
Rat Parathyroid Hormone (PTH) CLIA Kit |
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4-CCA866Ra | Cloud-Clone |
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Description: Competitive Inhibition chemiluminescent immunoassay for detection of Rat Parathyroid Hormone (PTH)Serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids |
Human Calcitonin Gene Related Peptide (CGRP) CLIA Kit |
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4-CCA876Hu | Cloud-Clone |
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Description: Competitive Inhibition chemiluminescent immunoassay for detection of Human Calcitonin Gene Related Peptide (CGRP)serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids |
Mouse Calcitonin Gene Related Peptide (CGRP) CLIA Kit |
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4-CCA876Mu | Cloud-Clone |
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Description: Competitive Inhibition chemiluminescent immunoassay for detection of Mouse Calcitonin Gene Related Peptide (CGRP)Serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids |
Rat Calcitonin Gene Related Peptide (CGRP) CLIA Kit |
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4-CCA876Ra | Cloud-Clone |
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Description: Competitive Inhibition chemiluminescent immunoassay for detection of Rat Calcitonin Gene Related Peptide (CGRP)Serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids |
General Vitamin D2 (VD2) CLIA Kit |
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4-CCA921Ge | Cloud-Clone |
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Description: Competitive Inhibition chemiluminescent immunoassay for detection of General Vitamin D2 (VD2)Serum, plasma and other biological fluids |
General Alpha-Tocopherol (TCPa) CLIA Kit |
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4-CCA922Ge | Cloud-Clone |
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Description: Competitive Inhibition chemiluminescent immunoassay for detection of General Alpha-Tocopherol (TCPa)Serum, plasma and other biological fluids |
Cattle Aprotinin (AP) CLIA Kit |
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4-CCA968Bo | Cloud-Clone |
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Description: Competitive Inhibition chemiluminescent immunoassay for detection of Cattle Aprotinin (AP)serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids |
Gallus Ghrelin (GHRL) CLIA Kit |
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4-CCA991Ga | Cloud-Clone |
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Description: Competitive Inhibition chemiluminescent immunoassay for detection of Gallus Ghrelin (GHRL)Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids |
General Estrone (E1) CLIA Kit |
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4-CCB003Ge | Cloud-Clone |
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Description: Competitive Inhibition chemiluminescent immunoassay for detection of General Estrone (E1)Serum, plasma and other biological fluids |
Human Albumin (ALB) CLIA Kit |
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4-CCB028Hu | Cloud-Clone |
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Description: Competitive Inhibition chemiluminescent immunoassay for detection of Human Albumin (ALB)Serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids |
Mouse Albumin (ALB) CLIA Kit |
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4-CCB028Mu | Cloud-Clone |
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Description: Competitive Inhibition chemiluminescent immunoassay for detection of Mouse Albumin (ALB)Serum, plasma and other biological fluids |
Rat Albumin (ALB) CLIA Kit |
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4-CCB028Ra | Cloud-Clone |
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Description: Competitive Inhibition chemiluminescent immunoassay for detection of Rat Albumin (ALB)Serum, plasma and other biological fluids |
Human Galanin (GAL) CLIA Kit |
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4-CCB084Hu | Cloud-Clone |
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Description: Competitive Inhibition chemiluminescent immunoassay for detection of Human Galanin (GAL)Serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids |
Rat Galanin (GAL) CLIA Kit |
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4-CCB084Ra | Cloud-Clone |
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Description: Competitive Inhibition chemiluminescent immunoassay for detection of Rat Galanin (GAL)Serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids |
Human Antidiuretic Hormone (ADH) CLIA Kit |
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4-CCB139Hu | Cloud-Clone |
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Description: Competitive Inhibition chemiluminescent immunoassay for detection of Human Antidiuretic Hormone (ADH)Serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids |
Mouse Antidiuretic Hormone (ADH) CLIA Kit |
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4-CCB139Mu | Cloud-Clone |
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Description: Competitive Inhibition chemiluminescent immunoassay for detection of Mouse Antidiuretic Hormone (ADH)Serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids |
Human Hemoglobin (HB) CLIA Kit |
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4-CCB409Hu | Cloud-Clone |
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Description: Competitive Inhibition chemiluminescent immunoassay for detection of Human Hemoglobin (HB)Serum, plasma, tissue homogenates, erythrocyte lysates, cell culture supernates and other biological fluids |
General Ovalbumin (OVA) CLIA Kit |
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4-CCB459Ge | Cloud-Clone |
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Description: Competitive Inhibition chemiluminescent immunoassay for detection of General Ovalbumin (OVA)Tissue homogenates, cell lysates and other biological fluids |
General Arginine (Arg) CLIA Kit |
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4-CCB938Ge | Cloud-Clone |
|
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Description: Competitive Inhibition chemiluminescent immunoassay for detection of General Arginine (Arg)serum, plasma, tissue homogenates and other biological fluids |
Human Fibroblast Growth Factor 13 (FGF13) CLIA Kit |
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4-CCC915Hu | Cloud-Clone |
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Description: Competitive Inhibition chemiluminescent immunoassay for detection of Human Fibroblast Growth Factor 13 (FGF13)serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids |
Rat Fibroblast Growth Factor 21 (FGF21) CLIA Kit |
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4-CCC918Ra | Cloud-Clone |
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Description: Competitive Inhibition chemiluminescent immunoassay for detection of Rat Fibroblast Growth Factor 21 (FGF21)Serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids |
General Vitamin B1 (VB1) CLIA Kit |
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4-CCD053Ge | Cloud-Clone |
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Description: Competitive Inhibition chemiluminescent immunoassay for detection of General Vitamin B1 (VB1)Serum, plasma and other biological fluids |
General Calcitroic Acid (CA) CLIA Kit |
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4-CCO007Ge | Cloud-Clone |
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Description: Competitive Inhibition chemiluminescent immunoassay for detection of General Calcitroic Acid (CA)Biological agents |
Human Angiotensin 1-7 (Ang1-7) CLIA Kit |
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4-CCS085Hu | Cloud-Clone |
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Description: Competitive Inhibition chemiluminescent immunoassay for detection of Human Angiotensin 1-7 (Ang1-7)serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids |
OVA Conjugated Complement Component 5a (C5a) |
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4-CPA388Ca21 | Cloud-Clone |
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Description: Recombinant Dog Complement Component 5a expressed in: Protein conjugation |
OVA Conjugated Substance P (SP) |
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4-CPA393Mi21 | Cloud-Clone |
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Description: Recombinant Human, Mouse, Rat Substance P expressed in: Protein conjugation |
KLH conjugated Inhibin A (INHA) |
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4-CPA395Hu31 | Cloud-Clone |
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Description: Recombinant Human Inhibin A expressed in: Protein conjugation |
BSA Conjugated Dehydroepiandrosterone (DHEA) |
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4-CPA398Ge11 | Cloud-Clone |
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Description: Recombinant Pan-species Dehydroepiandrosterone expressed in: Protein conjugation |
OVA Conjugated Dehydroepiandrosterone (DHEA) |
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4-CPA398Ge21 | Cloud-Clone |
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Description: Recombinant Pan-species Dehydroepiandrosterone expressed in: Protein conjugation |
OVA conjugated Mucin 1 (MUC1) |
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4-CPA413Hu21 | Cloud-Clone |
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Description: Recombinant Human Mucin 1 expressed in: Protein conjugation |
OVA Conjugated Synaptophysin (SYP) |
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4-CPA425Hu21 | Cloud-Clone |
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Description: Recombinant Human Synaptophysin expressed in: Protein conjugation |
BSA Conjugated Neurokinin A (NKA) |
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4-CPA428Hu11 | Cloud-Clone |
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Description: Recombinant Human Neurokinin A expressed in: Protein conjugation |
OVA conjugated Neurokinin A (NKA) |
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4-CPA428Hu21 | Cloud-Clone |
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Description: Recombinant Human Neurokinin A expressed in: Protein conjugation |
OVA conjugated Luteinizing Hormone (LH) |
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4-CPA441Hu21 | Cloud-Clone |
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Description: Recombinant Human Luteinizing Hormone expressed in: Protein conjugation |
BSA Conjugated Dihydrotestosterone (DHT) |
|||
4-CPA443Ge11 | Cloud-Clone |
|
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Description: Recombinant Pan-species Dihydrotestosterone expressed in: Protein conjugation |
Genetic analysis of youngsters with congenital ocular anomalies in three ecological areas of Nepal: a piece II of Nepal pediatric ocular diseases analysis
Background: Genetic eye diseases characterize a giant and heterogeneous group of childhood ocular morbidity. Explicit particular person diseases might set off quite a few structural anomalies and developmental choices.
Nepal Pediatric Ocular Sickness Analysis (NPODS) was a population-based epidemiological analysis carried out all through three ecological areas of Nepal to seek out out the prevalence and etiology of childhood ocular morbidity and blindness. In Half II of this analysis, genetic analysis was carried out for youths who’ve been found to have congenital ocular anomalies.
Methodology: It was a cross sectional descriptive analysis. An entire of 10,270 kids all through three completely totally different ecological areas in Nepal (Low lands, hills, and mountains) underwent ocular examinations in NPODS.
Out of 374 (3.6%) of youngsters with ocular abnormalities, 30 have been thought of congenital in nature. Centered genetic analysis, along with genotyping for genes specific to presenting phenotype, was carried out for 25 kids using serum samples.
Outcomes: Out of 25 kids, 18 had vital genetic outcomes. Analysis revealed one missense alteration G12411T of Zinc Finger Homeobox 4 (ZFHX4) gene in a single participant amongst 10 with congenital ptosis and one different missense variation T > C P. Y374 C of Signaling Receptor and Transporter Retinol 6 (STRA6) gene in a single participant amongst Three with microphthalmos.
Conclusion: The analysis is first of its type from Nepal and mutant genes have been distinctive to Nepalese Inhabitants. Further analysis of genetic parts is important to greater understand genetic affiliation with ocular diseases and conditions. This helps further in genetic counseling and probably gene treatment to forestall blindness from these conditions.
Subsequent era sequencing reveals a novel pathogenic variant within the ATMgene
Introduction: Ataxia telangiectasia (A-T) is a unusual autosomal recessive multisystemic sickness. Victims with the A-T syndrome present a broad spectrum of sickness phenotypes. The ATM (ataxia telangiectasia mutated) gene, the one causative gene for A-T.
Methodology: A affected particular person of Persian origin presenting with typical A-T was referred to our genetics center for specialised genetic counseling and testing. Centered next-generation sequencing (NGS) was utilized.
Sanger sequencing was used to substantiate the candidate variant. Modeling was carried out using the SWISS-MODEL server.Outcomes: A homozygous stop-gain variant c.829G > T (p.E277*) was found throughout the ATM gene. This variant was confirmed by Sanger sequencing and modeling of native development and truncated development was carried out.
Conclusion: To this point, just a few pathogenic variants of the ATM gene have been reported from the Iranian inhabitants. The discovering has implications in molecular diagnostic for A-T in Iran.
Familial dilated cardiomyopathy introduced on by a novel variant throughout the Lamin A/C gene: a case report
Background: Familial dilated cardiomyopathy (FDCM) is usually inherited as an autosomal dominant trait. The Lamin A/C (LMNA) gene variants have been acknowledged to be associated to DCM, conductive system issues, form 2 Emery-Dreifuss muscular dystrophy and quite a few different totally different issues. Proper right here, we reported a novel variant throughout the LMNA gene that’s more likely to be related to FDCM.
Case presentation: A 30-year-old youthful man was hospitalized for chest tightness, extreme fatigue, palpitation and impaired train tolerance. He had scientific traits along with cardiac dilatation, atrial tachyarrhythmia, excessive conductive system issues, and dyskinesia of every greater limbs and the neck. Genetic sequence analysis indicated that the affected particular person carried a novel c.1325 T>C heterozygous LMNA gene variant. Catheter ablation and cardiac resynchronization treatment with pacing carry out (CRT-P) have been carried out to take care of the arrhythmia.
Conclusion: The variant c.1325 T>C is a novel variant throughout the LMNA gene that has not been beforehand reported. Youthful victims with DCM, conductive system issues and skeletal myopathy should be alert to the potential for LMNA gene variant. Cardiac resynchronization treatment (CRT) may be an reasonably priced choice for affected particular person carrying a LMNA gene variant with third-degree atrioventricular block even when the left ventricular ejection fraction is preserved with the intention to cease the deterioration of cardiac carry out introduced on by correct ventricular pacing dependency.
Doxorubicin (hydrochloride) |
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HY-15142 | MedChemExpress | 100mg | EUR 176.4 |
Doxorubicin hydrochloride |
|||
GA4969-100MG | Glentham Life Sciences | 100 mg | EUR 217.2 |
Doxorubicin hydrochloride |
|||
GA4969-10MG | Glentham Life Sciences | 10 mg | EUR 93.6 |
Doxorubicin hydrochloride |
|||
GA4969-25MG | Glentham Life Sciences | 25 mg | EUR 117.6 |
Doxorubicin hydrochloride |
|||
GA4969-50MG | Glentham Life Sciences | 50 mg | EUR 151.2 |
Doxorubicin hydrochloride |
|||
TNC00267 | ChemNorm | 20mg | Ask for price |
Doxorubicin hydrochloride USP |
|||
D005-10MG | TOKU-E | 10 mg | EUR 199.2 |
Doxorubicin hydrochloride USP |
|||
D005-25MG | TOKU-E | 25 mg | EUR 361.2 |
Doxorubicin Hydrochloride (Autophagy inducer) |
|||
SIH-390-10MG | Stressmarq | 10 mg | EUR 231.6 |
Description: The substance Doxorubicin Hydrochloride is a autophagy inducer. It is synthetically produced and has a purity of >98%. The pure substance is red solid which is soluble in water (50 mM).. |
Doxorubicin Hydrochloride (Autophagy inducer) |
|||
SIH-390-50MG | Stressmarq | 50 mg | EUR 634.8 |
Description: The substance Doxorubicin Hydrochloride is a autophagy inducer. It is synthetically produced and has a purity of >98%. The pure substance is red solid which is soluble in water (50 mM).. |
Erlotinib, Hydrochloride Salt |
|||
1588-100 | Biovision | each | EUR 202.8 |
Erlotinib, Hydrochloride Salt |
|||
1588-1000 | Biovision | each | EUR 477.6 |
Doxorubicin |
|||
A3966-10 | ApexBio | 10 mg | EUR 129.6 |
Description: Doxorubicin is a semi-synthesized anticancer agent derived from bacterial culture. [1] It is an anthracycline antibiotic. It is been widely used in blood cancers, solid tumors and sarcomas. |
Doxorubicin |
|||
A3966-100 | ApexBio | 100 mg | EUR 282 |
Description: Doxorubicin is a semi-synthesized anticancer agent derived from bacterial culture. [1] It is an anthracycline antibiotic. It is been widely used in blood cancers, solid tumors and sarcomas. |
Doxorubicin |
|||
A3966-25 | ApexBio | 25 mg | EUR 157.2 |
Description: Doxorubicin is a semi-synthesized anticancer agent derived from bacterial culture. [1] It is an anthracycline antibiotic. It is been widely used in blood cancers, solid tumors and sarcomas. |
Doxorubicin |
|||
A3966-5.1 | ApexBio | 10 mM (in 1mL DMSO) | EUR 157.2 |
Description: Doxorubicin is a semi-synthesized anticancer agent derived from bacterial culture. [1] It is an anthracycline antibiotic. It is been widely used in blood cancers, solid tumors and sarcomas. |
Doxorubicin |
|||
A3966-S | ApexBio | Evaluation Sample |