Bioinformatics evaluation and identification of genes and molecular pathways in steroid-induced osteonecrosis of the femoral head
Background: Steroid-induced osteonecrosis of the femoral head (ONFH) is a typical hip joint illness and is tough to be recognized early. At current, the pathogenesis of steroid-induced ONFH stays unclear, and acknowledged and efficient diagnostic biomarkers are poor. The current research aimed to establish probably necessary genes and signaling pathways concerned in steroid-induced ONFH and examine their molecular mechanisms.
Strategies: Microarray knowledge units GSE123568 (peripheral blood) and GSE74089 (cartilage) have been obtained from the Gene Expression Omnibus database, together with 34 ONFH samples and 14 management samples. Morpheus software program and Venn diagram have been used to establish DEGs and co-expressed DEGs, respectively.
Apart from, we carried out Kyoto Encyclopedia of Genome (KEGG) and gene ontology (GO) pathway enrichment evaluation. We assemble a protein-protein interplay (PPI) community by means of GEO2R and used cytoHubba to divide the PPI community into a number of sub-networks. Moreover, quantitative real-time polymerase chain response (qRT-PCR) was carried out to confirm the bioinformatics evaluation outcomes.
Outcomes: A complete of 118 intersecting DEGs have been obtained between the peripheral blood and cartilage samples, together with 40 upregulated genes and 78 downregulated genes. Then, GO and KEGG pathway enrichment evaluation revealed that upregulated DEGs centered on the signaling pathways associated to staphylococcus aureus an infection, leishmaniasis, antigen processing, and presentation, in addition to bronchial asthma and graft-versus-host illness.
Downregulated genes have been concentrated within the FoxO signaling pathway, AMPK signaling pathway, signaling pathway regulating stem cell pluripotency, and mTOR signaling pathway. Some hub genes with excessive interactions comparable to CXCR1, FPR1, MAPK1, FOXO3, FPR2, CXCR2, and TYROBP have been recognized within the PPI community.
The outcomes of qRT-PCR demonstrated that CXCR1, FPR1, and TYROBP have been upregulated whereas MAPK1 was downregulated in peripheral blood of steroid-induced ONFH sufferers. This was in line with the bioinformatics evaluation.
 Polyclonal FGF-2 Antibody |
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| APR00247G | Leading Biology | 0.1mg | EUR 484 |
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Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human FGF-2 . This antibody is tested and proven to work in the following applications: |
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Polyclonal FGF-2 Antibody |
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| APR00248G | Leading Biology | 0.1mg | EUR 484 |
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Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human FGF-2 . This antibody is tested and proven to work in the following applications: |
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 Polyclonal KGF/FGF-7 Antibody |
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| APR00249G | Leading Biology | 0.1mg | EUR 484 |
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Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human KGF/FGF-7 . This antibody is tested and proven to work in the following applications: |
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 Polyclonal FGF-8 Antibody |
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| APR00250G | Leading Biology | 0.1mg | EUR 484 |
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Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human FGF-8 . This antibody is tested and proven to work in the following applications: |
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 Polyclonal FGF-10 Antibody |
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| APR00251G | Leading Biology | 0.1mg | EUR 484 |
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Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human FGF-10 . This antibody is tested and proven to work in the following applications: |
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Polyclonal FGF-10 Antibody |
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| APR00252G | Leading Biology | 0.1mg | EUR 484 |
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Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human FGF-10 . This antibody is tested and proven to work in the following applications: |
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 Polyclonal Flt3 Ligand Antibody |
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| APR00253G | Leading Biology | 0.1mg | EUR 484 |
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Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human Flt3 Ligand . This antibody is tested and proven to work in the following applications: |
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 Polyclonal Fractalkine Antibody |
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| APR00254G | Leading Biology | 0.1mg | EUR 484 |
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Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human Fractalkine . This antibody is tested and proven to work in the following applications: |
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 Polyclonal G-CSF Antibody |
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| APR00255G | Leading Biology | 0.1mg | EUR 484 |
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Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human G-CSF . This antibody is tested and proven to work in the following applications: |
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Polyclonal G-CSF Antibody |
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| APR00256G | Leading Biology | 0.1mg | EUR 484 |
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Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human G-CSF . This antibody is tested and proven to work in the following applications: |
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 Polyclonal GM-CSF Antibody |
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| APR00257G | Leading Biology | 0.1mg | EUR 484 |
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Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human GM-CSF . This antibody is tested and proven to work in the following applications: |
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Polyclonal GM-CSF Antibody |
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| APR00258G | Leading Biology | 0.1mg | EUR 484 |
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Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human GM-CSF . This antibody is tested and proven to work in the following applications: |
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Polyclonal GM-CSF Antibody |
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| APR00259G | Leading Biology | 0.05mg | EUR 484 |
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Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human GM-CSF . This antibody is tested and proven to work in the following applications: |
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 Polyclonal IL-7 Antibody |
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| APR00260G | Leading Biology | 0.05mg | EUR 484 |
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Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human IL-7 . This antibody is tested and proven to work in the following applications: |
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 Polyclonal IL-9 Antibody |
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| APR00261G | Leading Biology | 0.05mg | EUR 484 |
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Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human IL-9 . This antibody is tested and proven to work in the following applications: |
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 Polyclonal IL-17A Antibody |
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| APR00262G | Leading Biology | 0.05mg | EUR 484 |
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Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human IL-17A . This antibody is tested and proven to work in the following applications: |
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 Polyclonal IL-17F Antibody |
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| APR00263G | Leading Biology | 0.05mg | EUR 484 |
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Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human IL-17F . This antibody is tested and proven to work in the following applications: |
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 Polyclonal IL-33 Antibody |
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| APR00264G | Leading Biology | 0.05mg | EUR 484 |
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Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human IL-33 . This antibody is tested and proven to work in the following applications: |
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 Polyclonal sRANK Ligand Antibody |
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| APR00265G | Leading Biology | 0.05mg | EUR 484 |
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Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human sRANK Ligand . This antibody is tested and proven to work in the following applications: |
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 Polyclonal IFN gamma Antibody |
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| APR00266G | Leading Biology | 0.1mg | EUR 484 |
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Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human IFN gamma . This antibody is tested and proven to work in the following applications: |
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Polyclonal IFN gamma Antibody |
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| APR00267G | Leading Biology | 0.1mg | EUR 484 |
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Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human IFN gamma . This antibody is tested and proven to work in the following applications: |
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 Polyclonal IGF-I Antibody |
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| APR00268G | Leading Biology | 0.1mg | EUR 484 |
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Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human IGF-I . This antibody is tested and proven to work in the following applications: |
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 Polyclonal Anti-Rat IGF-1 Antibody |
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| APR00269G | Leading Biology | 0.1mg | EUR 484 |
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Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human Anti-Rat IGF-1 . This antibody is tested and proven to work in the following applications: |
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 Polyclonal IGF-II Antibody |
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| APR00270G | Leading Biology | 0.1mg | EUR 484 |
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Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human IGF-II . This antibody is tested and proven to work in the following applications: |
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 Polyclonal IL-2 Antibody |
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| APR00271G | Leading Biology | 0.1mg | EUR 484 |
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Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human IL-2 . This antibody is tested and proven to work in the following applications: |
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 Polyclonal IL-3 Antibody |
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| APR00272G | Leading Biology | 0.1mg | EUR 484 |
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Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human IL-3 . This antibody is tested and proven to work in the following applications: |
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Polyclonal IL-7 Antibody |
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| APR00273G | Leading Biology | 0.1mg | EUR 484 |
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Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human IL-7 . This antibody is tested and proven to work in the following applications: |
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 Polyclonal IL-8 Antibody |
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| APR00274G | Leading Biology | 0.1mg | EUR 484 |
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Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human IL-8 . This antibody is tested and proven to work in the following applications: |
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 Polyclonal IL-21 Antibody |
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| APR00275G | Leading Biology | 0.1mg | EUR 484 |
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Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human IL-21 . This antibody is tested and proven to work in the following applications: |
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 Polyclonal IP-10 Antibody |
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| APR00276G | Leading Biology | 0.1mg | EUR 484 |
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Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human IP-10 . This antibody is tested and proven to work in the following applications: |
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Polyclonal IP-10 Antibody |
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| APR00277G | Leading Biology | 0.1mg | EUR 484 |
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Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human IP-10 . This antibody is tested and proven to work in the following applications: |
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 Polyclonal CCR10 Antibody |
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| APR00278G | Leading Biology | 0.1mg | EUR 484 |
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Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human CCR10 . This antibody is tested and proven to work in the following applications: |
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 Polyclonal LIF Antibody |
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| APR00279G | Leading Biology | 0.1mg | EUR 484 |
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Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human LIF . This antibody is tested and proven to work in the following applications: |
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 Polyclonal RANKL Antibody |
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| APR00280G | Leading Biology | 0.1mg | EUR 484 |
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Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human RANKL . This antibody is tested and proven to work in the following applications: |
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 Polyclonal ApoSAA Antibody |
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| APR00281G | Leading Biology | 0.1mg | EUR 484 |
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Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human ApoSAA . This antibody is tested and proven to work in the following applications: |
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 Polyclonal TGF-alpha Antibody |
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| APR00282G | Leading Biology | 0.1mg | EUR 484 |
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Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human TGF-alpha . This antibody is tested and proven to work in the following applications: |
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 Polyclonal TGF-beta3 Antibody |
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| APR00283G | Leading Biology | 0.1mg | EUR 484 |
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Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human TGF-beta3 . This antibody is tested and proven to work in the following applications: |
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 Polyclonal TNF-beta Antibody |
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| APR00284G | Leading Biology | 0.1mg | EUR 484 |
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Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human TNF-beta . This antibody is tested and proven to work in the following applications: |
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 Polyclonal TNF-R1 Antibody |
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| APR00285G | Leading Biology | 0.1mg | EUR 484 |
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Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human TNF-R1 . This antibody is tested and proven to work in the following applications: |
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 Polyclonal CX3CR1/RBS11 Antibody |
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| APR00286G | Leading Biology | 0.1mg | EUR 484 |
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Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human CX3CR1/RBS11 . This antibody is tested and proven to work in the following applications: |
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 Polyclonal CXCR4 Antibody |
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| APR00287G | Leading Biology | 0.1mg | EUR 484 |
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Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human CXCR4 . This antibody is tested and proven to work in the following applications: |
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 Polyclonal FGF-19 Antibody |
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| APR00288G | Leading Biology | 0.1mg | EUR 484 |
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Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human FGF-19 . This antibody is tested and proven to work in the following applications: |
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 Polyclonal C3aR Antibody |
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| APR00289G | Leading Biology | 0.1mg | EUR 484 |
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Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human C3aR . This antibody is tested and proven to work in the following applications: |
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 Polyclonal IL-19 Antibody |
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| APR00290G | Leading Biology | 0.1mg | EUR 484 |
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Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human IL-19 . This antibody is tested and proven to work in the following applications: |
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 Polyclonal BLC Antibody |
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| APR00291G | Leading Biology | 0.1mg | EUR 484 |
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Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human BLC . This antibody is tested and proven to work in the following applications: |
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 Polyclonal CTGF Antibody |
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| APR00292G | Leading Biology | 0.1mg | EUR 484 |
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Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human CTGF . This antibody is tested and proven to work in the following applications: |
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 Polyclonal IL-21R Antibody |
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| APR00293G | Leading Biology | 0.1mg | EUR 484 |
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Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human IL-21R . This antibody is tested and proven to work in the following applications: |
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 Polyclonal sRANK Ligand Polyclonal Antibody |
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| APR00294G | Leading Biology | 0.1mg | EUR 484 |
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Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human sRANK Ligand Polyclonal . This antibody is tested and proven to work in the following applications: |
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 Polyclonal MIF Antibody |
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| APR00295G | Leading Biology | 0.1mg | EUR 484 |
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Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human MIF . This antibody is tested and proven to work in the following applications: |
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 Polyclonal BMP-5 Antibody |
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| APR00296G | Leading Biology | 0.1mg | EUR 484 |
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Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human BMP-5 . This antibody is tested and proven to work in the following applications: |
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 Polyclonal BMP-14 Antibody |
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| APR00297G | Leading Biology | 0.1mg | EUR 484 |
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Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human BMP-14 . This antibody is tested and proven to work in the following applications: |
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 Polyclonal BMP-10 Antibody |
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| APR00298G | Leading Biology | 0.1mg | EUR 484 |
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Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human BMP-10 . This antibody is tested and proven to work in the following applications: |
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 Polyclonal Leptin Receptor Antibody |
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| APR00299G | Leading Biology | 0.1mg | EUR 484 |
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Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human Leptin Receptor . This antibody is tested and proven to work in the following applications: |
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 Polyclonal FGF-20 Antibody |
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| APR00300G | Leading Biology | 0.1mg | EUR 484 |
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Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human FGF-20 . This antibody is tested and proven to work in the following applications: |
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 Polyclonal IFN alpha 2b Antibody |
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| APR00301G | Leading Biology | 0.1mg | EUR 484 |
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Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human IFN alpha 2b . This antibody is tested and proven to work in the following applications: |
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 Polyclonal IFN alpha Antibody |
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| APR00302G | Leading Biology | 0.1mg | EUR 484 |
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Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human IFN alpha . This antibody is tested and proven to work in the following applications: |
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Polyclonal IFN alpha Antibody |
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| APR00303G | Leading Biology | 0.1ml | EUR 528 |
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Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human IFN alpha . This antibody is tested and proven to work in the following applications: |
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 Polyclonal HDAC8 Antibody |
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| APR00304G | Leading Biology | 0.1mg | EUR 484 |
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Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human HDAC8 . This antibody is tested and proven to work in the following applications: |
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 Polyclonal TGF-beta Receptor I Antibody |
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| APR00305G | Leading Biology | 0.1mg | EUR 484 |
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Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human TGF-beta Receptor I . This antibody is tested and proven to work in the following applications: |
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 Polyclonal VEGF-B Antibody |
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| APR00306G | Leading Biology | 0.1mg | EUR 484 |
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Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human VEGF-B . This antibody is tested and proven to work in the following applications: |
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 Polyclonal VEGF-D Antibody |
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| APR00307G | Leading Biology | 0.1mg | EUR 484 |
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Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human VEGF-D . This antibody is tested and proven to work in the following applications: |
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 Polyclonal Galectin-7 Antibody |
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| APR00308G | Leading Biology | 0.1mg | EUR 484 |
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Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human Galectin-7 . This antibody is tested and proven to work in the following applications: |
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 Polyclonal TCR beta Antibody |
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| APR00309G | Leading Biology | 0.1mg | EUR 484 |
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Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human TCR beta . This antibody is tested and proven to work in the following applications: |
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 Polyclonal PTHrP Antibody |
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| APR00310G | Leading Biology | 0.1mg | EUR 484 |
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Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human PTHrP . This antibody is tested and proven to work in the following applications: |
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 Polyclonal RELM-beta Antibody |
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| APR00311G | Leading Biology | 0.1mg | EUR 484 |
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Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human RELM-beta . This antibody is tested and proven to work in the following applications: |
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 Polyclonal BMP-2 Antibody |
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| APR00312G | Leading Biology | 0.1mg | EUR 484 |
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Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human BMP-2 . This antibody is tested and proven to work in the following applications: |
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 Polyclonal BMP-4 Antibody |
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| APR00313G | Leading Biology | 0.1mg | EUR 484 |
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Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human BMP-4 . This antibody is tested and proven to work in the following applications: |
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Polyclonal BMP-4 Antibody |
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| APR00314G | Leading Biology | 0.1mg | EUR 484 |
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Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human BMP-4 . This antibody is tested and proven to work in the following applications: |
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Polyclonal BMP-5 Antibody |
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| APR00315G | Leading Biology | 0.1mg | EUR 484 |
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Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human BMP-5 . This antibody is tested and proven to work in the following applications: |
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 Polyclonal BMP-6 Antibody |
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| APR00316G | Leading Biology | 0.1mg | EUR 484 |
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Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human BMP-6 . This antibody is tested and proven to work in the following applications: |
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 Polyclonal IGF-BP5 Antibody |
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| APR00317G | Leading Biology | 0.1mg | EUR 484 |
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Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human IGF-BP5 . This antibody is tested and proven to work in the following applications: |
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 Polyclonal IL-12p40 Antibody |
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| APR00318G | Leading Biology | 0.1mg | EUR 484 |
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Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human IL-12p40 . This antibody is tested and proven to work in the following applications: |
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 Polyclonal TFF-2/Spasmolysin Antibody |
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| APR00319G | Leading Biology | 0.1mg | EUR 484 |
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Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human TFF-2/Spasmolysin . This antibody is tested and proven to work in the following applications: |
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 Polyclonal Wnt-1 Antibody |
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| APR00320G | Leading Biology | 0.1mg | EUR 484 |
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Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human Wnt-1 . This antibody is tested and proven to work in the following applications: |
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 Polyclonal MMP-3 Antibody |
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| APR00321G | Leading Biology | 0.1mg | EUR 484 |
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Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human MMP-3 . This antibody is tested and proven to work in the following applications: |
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 Polyclonal Endostatin Antibody |
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| APR00322G | Leading Biology | 0.1mg | EUR 484 |
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Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human Endostatin . This antibody is tested and proven to work in the following applications: |
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 Polyclonal MART-1/Melan-A Antibody |
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| APR00323G | Leading Biology | 0.1mg | EUR 484 |
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Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human MART-1/Melan-A . This antibody is tested and proven to work in the following applications: |
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 Polyclonal HSP90 Antibody |
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| APR00324G | Leading Biology | 0.1mg | EUR 484 |
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Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human HSP90 . This antibody is tested and proven to work in the following applications: |
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 Polyclonal HSP70 antibody |
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| APR00325G | Leading Biology | 0.1mg | EUR 484 |
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Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human HSP70 . This antibody is tested and proven to work in the following applications: |
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 Polyclonal Placental Lactogen Antibody |
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| APR00326G | Leading Biology | 0.1mg | EUR 484 |
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Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human Placental Lactogen . This antibody is tested and proven to work in the following applications: |
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 Polyclonal GDF-9 Antibody |
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| APR00327G | Leading Biology | 0.1mg | EUR 484 |
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Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human GDF-9 . This antibody is tested and proven to work in the following applications: |
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 Polyclonal JMJD6 Antibody |
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| APR00328G | Leading Biology | 0.05mg | EUR 484 |
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Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human JMJD6 . This antibody is tested and proven to work in the following applications: |
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 Polyclonal USP1 Antibody |
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| APR00329G | Leading Biology | 0.1mg | EUR 528 |
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Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human USP1 . This antibody is tested and proven to work in the following applications: |
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 Polyclonal USP2 Antibody |
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| APR00330G | Leading Biology | 0.1mg | EUR 528 |
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Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human USP2 . This antibody is tested and proven to work in the following applications: |
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 Polyclonal USP25 Antibody |
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| APR00331G | Leading Biology | 0.1mg | EUR 528 |
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Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human USP25 . This antibody is tested and proven to work in the following applications: |
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 Polyclonal UHRF2 Antibody |
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| APR00332G | Leading Biology | 0.1mg | EUR 528 |
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Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human UHRF2 . This antibody is tested and proven to work in the following applications: |
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 Polyclonal BMI 1 Antibody |
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| APR00333G | Leading Biology | 0.1mg | EUR 528 |
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Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human BMI 1 . This antibody is tested and proven to work in the following applications: |
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 Polyclonal EHMT2 Antibody |
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| APR00334G | Leading Biology | 0.1mg | EUR 528 |
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Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human EHMT2 . This antibody is tested and proven to work in the following applications: |
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 Polyclonal RBBP4 Antibody |
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| APR00335G | Leading Biology | 0.1mg | EUR 528 |
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Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human RBBP4 . This antibody is tested and proven to work in the following applications: |
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 Polyclonal SMARCA4 Antibody |
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| APR00336G | Leading Biology | 0.1mg | EUR 528 |
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Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human SMARCA4 . This antibody is tested and proven to work in the following applications: |
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Affiliation analysis of the surfactant protein-C gene to childhood bronchial bronchial asthma
Targets: This analysis targets to clarify the molecular variability throughout the SFTPC gene in a childhood persistent respiratory sickness, bronchial bronchial asthma, throughout the Tunisian inhabitants and to determine the implications based on a case-control analysis of p.Thr138Asn (T138N) and p.Ser186Asn (S186N) variants.
Methods: We used direct sequencing for the genotyping of the SFTPC gene inside 101 asthmatic children. The analysis of T138N and S186N variants in 110 controls is carried out by the PCR-RFLP methodology. Outcomes: The molecular analysis revealed 26 variants along with 24 intronic variations and a pair of exonic variations (T138N and S186N) with respective frequencies of 16.8% and 18.3%. We carried out a case-control analysis of the two acknowledged exonic
variations. A particular genotypic and allelic distribution between the two groups was well-known. Solely the T138N polymorphism confirmed a serious affiliation with bronchial bronchial asthma sickness (p < 10-3).
Statistical analysis elaborated Four haplotypes with the following frequencies in victims vs controls: 138Thr-186Ser (79.5% vs 57.6%), 138Thr-186Asn (3.7% vs 7.8%), 138Asn-186Thr (2.2% vs 20.2%) and 138Asn-186Asn (14.6% vs 14.4%). A serious distinction (p < 10-3) was highlighted in haplotype distribution.
The 138Asn-186Ser (OR [95%CI] = 0.14[0.04-0.54], p = 0.004, R2=0.93) and 138Thr-186Asn (OR [95%CI] = 0.35[0.12-0.54], p = 0.047, R2=0.88) haplotypes confirmed a dangerous affiliation with bronchial bronchial asthma which might signify a defending challenge in opposition to the sickness.
Conclusion: In Tunisia, this work constitutes the first report throughout the SFTPC gene and highlights the genetic variability of the SFTPC gene in bronchial bronchial asthma. On account of this truth, the case-controls analysis may be useful throughout the analysis of surfactant proteins dysfunction in persistent respiratory sickness at an early age.
The genetic foundation of pure antibody titers of younger wholesome pigs and relationships with illness resilience
Background: Sickness resilience is the pliability to maintain up effectivity beneath pathogen publicity nonetheless is troublesome to choose for on account of breeding populations are raised beneath extreme properly being. Selection for resilience requires a trait that is heritable, simple to measure on healthful animals, and genetically correlated with resilience.
Pure antibodies (NAb) are important parts of the innate immune system and are found to be heritable and associated to sickness susceptibility in dairy cattle and poultry. Our purpose was to investigate NAb and complete IgG in blood of healthful, youthful pigs as potential indicator traits for sickness resilience.
Outcomes: Info have been from Yorkshire x Landrace pigs, with IgG and IgM NAb (Four antigens) and complete IgG measured by ELISA in blood plasma collected ~ 1 week after weaning, earlier to their publicity to a pure polymicrobial downside.
Heritability estimates have been lower for IgG NAb (0.12 to 0.24, + 0.05) and for complete IgG (0.19 + 0.05) than for IgM NAb (0.33 to 0.53, + 0.07) nonetheless maternal outcomes have been larger for IgG NAb (0.41 to 0.52, + 0.03) and for complete IgG (0.19 + 0.05) than for IgM NAb (0.00 to 0.10, + 0.04).
Phenotypically, IgM NAb titers have been moderately correlated with each other (widespread 0.60), as have been IgG NAb titers (widespread 0.42), nonetheless correlations between IgM and IgG NAb titers have been weak (widespread 0.09). Phenotypic correlations of complete IgG have been cheap with NAb IgG (widespread 0.46) nonetheless weak with NAb IgM (widespread 0.01).
Estimates of genetic correlations amongst NAb confirmed associated patterns nonetheless with small SE, with estimates averaging 0.76 amongst IgG NAb, 0.63 amongst IgM NAb, 0.17 between IgG and IgM NAb, 0.64 between complete IgG and IgG NAb, and 0.13 between complete IgG and IgM NAb. Phenotypically, pigs that survived had barely elevated ranges of NAb and complete IgG than pigs that died.
Genetically, elevated ranges of NAb tended to be associated to raised sickness resilience based on lower mortality and fewer parenteral antibiotic therapies. Genome-wide affiliation analyses for NAb titers acknowledged a lot of genomic areas, with a lot of candidate genes for immune response.
Conclusions: Ranges of NAb in blood of healthful youthful piglets are heritable and potential genetic indicators of resilience to polymicrobial sickness.